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Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

  • US 9,895,424 B2
  • Filed: 01/08/2015
  • Issued: 02/20/2018
  • Est. Priority Date: 01/09/2014
  • Status: Active Grant
First Claim
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1. A pharmaceutical formulation consisting of:

  • (a) 3.5 mg/mL insulin aspart;

    (b) 1.72 mg/mL metacresol;

    (c) 1.50 mg/mL phenol;

    (d) 0.0196 mg/mL Zn(II);

    (e) 6.2 mg/mL sodium chloride;

    (f) 1.88 mg/mL Na2HPO4×

    7H2O;

    (g) from 0.1 mg/mL to 0.5 mg/mL protamine;

    (h) sodium hydroxide and/or hydrochloric acid to adjust the pH to a pH in the range from 7.1 to 7.6; and

    (i) water.

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