Water management system for use in dialysis

• US 9,895,479 B2
• Filed: 12/10/2014
• Issued: 02/20/2018
• Est. Priority Date: 12/10/2014
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Meyer, Thomas E.
• Primary Examiner(s): Yoo, Regina M
• Application Number:
  US14/566,677
• Publication Number:
  US 20160166753A1
• Time in Patent Office: 1,168 Days
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1682 both machine and membrane module, i.e. also the module blood side
• CPC Class Codes: A61M 1/1686 by heat
• CPC Class Codes: A61M 1/169 using chemical substances
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/3652 using gas, e.g. air
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/7518 bacterial

Abstract

A water management system for use in dialysis. The water management system includes apparatuses to generate purified water, and a reservoir for storing the purified water. The reservoir can be connected to a dialysate flow loop and the purified water can be generated, stored, and used for later cleaning and disinfection of the dialysis flow loop and the components thereon.

Claims

1. A water management system for use in sorbent dialysis comprising:

a rinse water reservoir configured to receive purified water obtained from a sorbent cartridge containing one or more sorbent materials, wherein the rinse water reservoir is fluidly connectable to a rinse water reservoir line, the rinse water reservoir line fluidly connectable to a dialysate circuit by one or more valves;

wherein the rinse water reservoir line is fluidly connectable to the dialysate circuit at a position upstream of the sorbent cartridge;

a water source, wherein the one or more valves are fluidly connectable to the water source and the sorbent cartridge,

wherein water from the water source is directed to the sorbent cartridge and the water is purified by the sorbent cartridge, and is stored in the rinse water reservoir; and

a drain, wherein the drain is fluidly connectable to at least one drain valve;

wherein the at least one drain valve is fluidly connectable to the dialysate circuit.

2. The water management system of claim 1 wherein the water management system is part of a controlled compliant dialysate circuit.

3. The water management system of claim 1, wherein the water source is a source water reservoir.

4. The water management system of claim 1, wherein the drain comprises a waste reservoir.

5. The water management system of claim 1 further comprising a microbial filter positioned in the fluid flow path after the sorbent cartridge and before a dialyzer, wherein the microbial filter is fluidly connectable to the rinse water reservoir.

6. The water management system of claim 1 further comprising one or more pumps to direct a fluid in the fluid flow path.

7. The water management system of claim 6 further comprising a programmable controller to control the one or more valves in the dialysate circuit, drain valve, and pumps.

8. The water management system in claim 1, wherein the sorbent cartridge receives water used in flushing the dialysate circuit.

9. The water management system in claim 1, wherein the sorbent cartridge is positioned downstream to the water source.

10. The water management system in claim 1, wherein the water from the water source is further directed through a microbial filter, and wherein the purified water is free from chemical and microbiological contamination.

11. The water management system of claim 1, further comprising a citric acid cartridge fluidly connectable to the dialysate circuit at a position downstream of the rinse water reservoir line.

12. A method of filling a rinse water reservoir of a water management system comprising the step of:

directing water from a water source, through a sorbent cartridge, and then into the rinse water reservoir;

wherein the rinse water reservoir is configured to receive purified water obtained from the sorbent cartridge containing one or more sorbent materials, wherein the rinse water reservoir is fluidly connectable to a rinse water reservoir line, the rinse water reservoir line fluidly connectable to a dialysate circuit by one or more valves;

wherein the rinse water reservoir line is fluidly connectable to the dialysate circuit at a position upstream of the sorbent cartridge;

wherein the water management system comprises the water source, wherein the one or more valves are fluidly connectable to the water source and the sorbent cartridge,

wherein the method comprises directing water from the water source to the sorbent cartridge, wherein the water is purified by the sorbent cartridge, and is stored in the rinse water reservoir; and

wherein the water management system comprises a drain, wherein the drain is fluidly connectable to at least one drain valve;

wherein the at least one drain valve is fluidly connectable to the dialysate circuit.

13. The method of claim 12 further comprising the step of directing water through a microbial filter prior to the step of directing water into the rinse water reservoir.

14. The method of claim 12 wherein the water from the water source travels through the dialysate circuit defining a fluid flow path before flowing into the rinse water reservoir.

15. The method of claim 14 further comprising the step of directing water from the water source through lines of a dialysis system and into the drain prior to the step of directing water from the water source through the sorbent cartridge and into the rinse water reservoir.

16. The method of claim 15 wherein the step of directing water from the water source through the lines of the dialysis system and into the drain is repeated multiple times prior to directing water into the rinse water reservoir.

17. The method of claim 15 wherein the step of directing water from the water source through the lines of the dialysis system and into the drain is repeated a pre-set number of times.

18. The method of claim 17 wherein the step of directing water from the water source through the lines of the dialysis system and into the drain is repeated any of 2, 3, 4, 5 or 6 times.

19. The method of claim 15 further comprising the step of taking a conductivity measurement after directing water from the water source through the lines of the dialysis system and into the drain;

and wherein the step of directing water from the water source through the lines of the dialysis system and into the drain is repeated until the conductivity measurement shows a conductivity below a pre-set number.

20. The method of claim 12 wherein a programmable controller operates one or more pumps and the one or more valves to direct the filling of the rinse water reservoir.

21. A method of disinfecting a dialysis system comprising the steps of:

directing purified water from a rinse water reservoir through lines of the dialysis system, wherein the purified water is produced by having water pass through a sorbent cartridge prior to the purified water being placed in the rinse water reservoir; and

circulating heated purified water through the dialysis system;

wherein the rinse water reservoir is configured to receive purified water obtained from the sorbent cartridge containing one or more sorbent materials, wherein the rinse water reservoir is fluidly connectable to a rinse water reservoir line, the rinse water reservoir line fluidly connectable to a dialysate circuit by one or more valves;

wherein the rinse water reservoir line is fluidly connectable to the dialysate circuit at a position upstream of the sorbent cartridge;

wherein the dialysis system comprises a water source, wherein the one or more valves are fluidly connectable to the water source and the sorbent cartridge,

wherein water from the water source is directed to the sorbent cartridge and the water is purified by the sorbent cartridge, and is stored in the rinse water reservoir; and

wherein the dialysis system comprises a drain, wherein the drain is fluidly connectable to at least one drain valve;

wherein the at least one drain valve is fluidly connectable to the dialysate circuit.

22. The method of claim 21 further comprising the steps of:

attaching a citric acid cartridge to the dialysis system;

directing water from the rinse water reservoir through the citric acid cartridge to create a citric acid solution; and

heating the citric acid solution and circulating the citric acid solution through the lines of the dialysis system.

23. The method of claim 22, wherein the dialysis system is heated to a temperature between any of 60-100°

C., 60-75°

C., 65-90°

C., 75-85°

C. or 85-100°

C. while circulating the citric acid solution.

24. The method of claim 21 further comprising the step of blowing out the lines of the dialysis system with air prior to directing purified water from the rinse water reservoir through the lines of the dialysis system.

25. The method of claim 22 wherein the citric acid cartridge contains dry citric acid.

26. The method of claim 25 wherein the citric acid cartridge contains a predetermined amount of citric acid, and further comprising the step of dissolving the dry citric acid with the purified water directed through the citric acid cartridge to create a citric acid solution of a predetermined concentration.