Cerebrospinal fluid purification system
First Claim
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1. A method for conditioning cerebrospinal fluid (CSF) in a patient, said method comprising:
- selecting a patient having a symptom of Alzheimer'"'"'s disease;
introducing a catheter apparatus into a first location in a CSF space of the patient, the catheter apparatus comprising a distal port and a proximal port spaced axially apart from one another;
withdrawing a volume of endogenous CSF from the first location through one of said ports at a first flow rate;
conditioning the withdrawn CSF; and
returning the conditioned CSF to the patient at a second location in the CSF space through the other of said ports at a second flow rate;
wherein the withdrawing and returning steps are performed concurrently during at least a portion of a conditioning treatment;
wherein the first and second flow rates are substantially the same rate;
wherein, while an initial volume of endogenous CSF is withdrawn from the first location through the one of said ports, a volume of fluid from a primed system is infused at substantially the same rate through the other of said ports;
wherein conditioning the withdrawn CSF comprises withdrawing proteins selected from a group consisting of tau proteins, IL-1, IL-2, IL-6, IL-12, and interferon-γ
; and
wherein withdrawing proteins selected from the group comprises withdrawing proteins using a combination of size, biospecific affinity, and charge-based selection criteria by contacting CSF with multiple substrates.
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Abstract
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
207 Citations
17 Claims
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1. A method for conditioning cerebrospinal fluid (CSF) in a patient, said method comprising:
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selecting a patient having a symptom of Alzheimer'"'"'s disease; introducing a catheter apparatus into a first location in a CSF space of the patient, the catheter apparatus comprising a distal port and a proximal port spaced axially apart from one another; withdrawing a volume of endogenous CSF from the first location through one of said ports at a first flow rate; conditioning the withdrawn CSF; and returning the conditioned CSF to the patient at a second location in the CSF space through the other of said ports at a second flow rate; wherein the withdrawing and returning steps are performed concurrently during at least a portion of a conditioning treatment; wherein the first and second flow rates are substantially the same rate; wherein, while an initial volume of endogenous CSF is withdrawn from the first location through the one of said ports, a volume of fluid from a primed system is infused at substantially the same rate through the other of said ports; wherein conditioning the withdrawn CSF comprises withdrawing proteins selected from a group consisting of tau proteins, IL-1, IL-2, IL-6, IL-12, and interferon-γ
; andwherein withdrawing proteins selected from the group comprises withdrawing proteins using a combination of size, biospecific affinity, and charge-based selection criteria by contacting CSF with multiple substrates. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 17)
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12. A method for conditioning cerebrospinal fluid (CSF) in a patient, said method comprising:
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selecting a patient having a symptom of Alzheimer'"'"'s disease; introducing a catheter apparatus into a first location in a CSF space of the patient, the catheter apparatus comprising a distal port and a proximal port spaced axially apart from one another; withdrawing a volume of endogenous CSF from the first location through one of said ports at a first flow rate; conditioning the withdrawn CSF; and returning the conditioned CSF to the patient at a second location in the CSF space through the other of said ports at a second flow rate; wherein the removing and returning steps are performed concurrently during at least a portion of a conditioning treatment; wherein the first and second flow rates are substantially the same rate; wherein, while an initial volume of endogenous CSF is withdrawn from the first location through the one of said ports, a volume of fluid from a primed system is infused at substantially the same rate through the other of said ports; wherein conditioning the withdrawn CSF comprises removing proteins selected from a group consisting of tau proteins, IL-1, IL-2, IL-6, IL-12, and interferon-γ
; andwherein removing proteins selected from the group comprises removing proteins using a combination of size, biospecific affinity, and charge-based selection criteria by contacting CSF with multiple substrates, wherein conditioning comprises processing CSF over an antibody cartridge comprising antibodies or antibody fragments secured to an ex-vivo immunoaffinity column, and wherein the method further comprises periodically re-using or re-charging the antibody cartridge, including using an eluent to release captured proteins and regenerate active antigen binding sites of the antibodies or antibody fragments. - View Dependent Claims (16)
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Specification