Treatment of cavities in a human body

• US 9,895,519 B2
• Filed: 10/06/2014
• Issued: 02/20/2018
• Est. Priority Date: 10/07/2013
• Status: Active Grant

• Current Assignee: Regentis Biomaterials Ltd.
• Original Assignee: Regentis Biomaterials Ltd.
• Inventors: Harari, Boaz, Perle, Amir, Simon, Raz
• Primary Examiner(s): MEDWAY, SCOTT J
• Application Number:
  US14/507,246
• Publication Number:
  US 20150100041A1
• Time in Patent Office: 1,233 Days
• CPC Class Codes: A61B 17/0218 for minimally invasive surgery A61B17/0281, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 17/8808 with sealing collar for bone cavity
• CPC Class Codes: A61B 18/08 by means of electrically-heated probes
• CPC Class Codes: A61B 2017/005 hardenable using external energy source, e.g. laser, ultrasound
• CPC Class Codes: A61B 2017/3488 Fixation to inner organ or inner body tissue
• CPC Class Codes: A61B 2090/0815 Implantable devices for insertion in between organs or other soft tissues
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 90/04 Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery protection of eyes against laser radiation A61F9/022
• CPC Class Codes: A61C 17/08 Aspiration nozzles
• CPC Class Codes: A61C 19/063 Medicament applicators for teeth or gums, e.g. treatment with fluorides
• CPC Class Codes: A61C 5/82 Dams; Holders or clamps therefor
• CPC Class Codes: A61F 2/30723 Plugs or restrictors for sealing a cement-receiving space tools for inserting plugs A61F2/4614; sealing collars for use during cementing A61B17/8808
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00

Abstract

Apparatus and methods are described, including apparatus for treating a cavity in a human body, the apparatus including a delivery tube. A bather device has a collapsed configuration and an expanded configuration, the barrier device moving from the collapsed configuration to the expanded configuration upon being deployed from the delivery tube. A pushing element, slidably disposed within a lumen of the delivery tube, is configured to deploy the barrier device from the delivery tube by pushing the bather device. One or more bather-deployment elements are coupled to the barrier device and to the pushing element, the bather-deployment elements being configured to conformingly contact the barrier device with tissue surrounding the cavity. Other applications are also described.

Claims

1. A method for treating a cavity in a human body using a barrier device having a collapsed configuration and an expanded configuration, the method comprising:

deploying the barrier device from a delivery tube, using a pushing element slidably disposed within a lumen of the delivery tube, the barrier device moving from the collapsed configuration to the expanded configuration upon being deployed; and

conformingly contacting the barrier device with tissue surrounding the cavity, using a plurality of barrier-deployment elements coupled at respective distal ends thereof to the barrier device and to the pushing element,

the cavity including at least one defect selected from the group consisting of;

a chondral defect, and an osteochondral defect,

wherein a first one of the barrier-deployment elements includes a spring, including;

a first spring-arm that is pivotably coupled to the pushing element at a proximal end of the first spring-arm; and

a second spring-arm that is pivotably coupled to the pushing element at a proximal end of the second spring-arm, wherein the proximal end of the second spring-arm is more longitudinally moveable with respect to the pushing element than is the proximal end of the first spring-arm.

2. The method according to claim 1, wherein conformingly contacting the barrier device with tissue surrounding the cavity comprises isolating the cavity from fluid between the barrier device and the pushing element.

3. The method according to claim 1, further comprising regulating a temperature of the cavity by using a temperature regulator to drive a heat-transfer element to transfer heat in a direction selected from the group consisting of:

to the cavity, and from the cavity.

4. The method according to claim 1, wherein the barrier-deployment elements include a plurality of legs, and wherein using the barrier-deployment elements comprises using the plurality of legs.

5. The method according to claim 4, wherein the plurality of legs includes at least one leg that is hingedly coupled to the pushing element, and wherein using the plurality of legs comprises using the at least one leg.

6. The method according to claim 1, wherein the barrier device includes a flexible sheet, and wherein deploying the barrier device comprises deploying the flexible sheet.

7. The method according to claim 1, further comprising suctioning fluid from the cavity using a suction tube.

8. The method according to claim 7, wherein:

the barrier device is shaped to define an opening therethrough,

the suction tube is coupled to the barrier device such that a lumen of the suction tube is in fluid communication with the opening, and

suctioning fluid from the cavity comprises suctioning fluid through the opening.

9. The method according to claim 1, wherein deploying the barrier device comprises deploying a transparent barrier device.

10. The method according to claim 9, further comprising viewing the cavity through the barrier device, using a scope.

11. The method according to claim 1, further comprising guiding light from a light source toward a distal end of the delivery tube.

12. The method according to claim 11, wherein guiding light comprises guiding ultraviolet light toward the distal end of the delivery tube.

13. The method according to claim 12, wherein the barrier device is transparent to ultraviolet light, and wherein the method further comprises passing ultraviolet light through the barrier device.

14. The method according to claim 1, further comprising delivering a therapeutic agent to the cavity via a therapeutic agent delivery tube.

15. The method according to claim 14, wherein:

the barrier device is shaped to define an opening therethrough,

the therapeutic agent delivery tube is coupled to the barrier device such that a lumen of the therapeutic agent delivery tube lumen is in fluid communication with the opening, and

delivering the therapeutic agent comprises delivering the therapeutic agent through the opening.

16. The method according to claim 1, wherein deploying the barrier device comprises deploying the barrier device such that an angle between (a) a longitudinal axis of the delivery tube, and (b) a normal to a plane defined by the barrier device upon deployment thereof from the delivery tube, is greater than 5 degrees.

17. The method according to claim 3, further comprising using a temperature sensor to sense a temperature of the cavity and communicate the sensed temperature to the temperature regulator, wherein regulating the temperature of the cavity comprises regulating the temperature in response to the sensed temperature.

20. The method according to claim 1, wherein the second spring-arm is longer than the first spring-arm.

21. The method according to claim 1, wherein a distal portion of the pushing element is shaped to define a channel, and wherein the proximal end of the second spring-arm is longitudinally moveable within the channel.

22. The method according to claim 21, wherein the distal portion of the pushing element is shaped to define a hole, wherein the first spring-arm is coupled to the pushing element by the proximal end of the first spring-arm fitting in the hole, and wherein a length of the channel is greater than a diameter of the hole.

23. The method according to claim 1, wherein the barrier device is configured to move from the collapsed configuration to the expanded configuration at least by the proximal end of the second spring-arm moving in a proximal direction.

24. The method according to claim 1, wherein the first and the second spring-arms converge at respective distal ends thereof.

25. The method according to claim 1, wherein the proximal end of the second spring-arm is axially slidable with respect to the pushing element, and the proximal end of the first spring-arm is axially fixed with respect to the pushing element.

26. The method according to claim 1, wherein the barrier device includes a plurality of hinges, and wherein the first and the second spring-arms are hingedly coupled to the barrier device by exactly one of the hinges.

27. The method according to claim 4,

wherein the barrier device includes a plurality of hinges, which are distinct from the legs and are fixed to a proximal surface of the barrier device,

wherein the legs are hingedly coupled to the hinges, such that the legs are pivotable with respect to the hinges.

18. A method for treating a cavity in a human body using a barrier device having a collapsed configuration and an expanded configuration, the method comprising:

deploying the barrier device from a delivery tube, using a pushing element slidably disposed within a lumen of the delivery tube, the barrier device moving from the collapsed configuration to the expanded configuration upon being deployed; and

conformingly contacting the barrier device with tissue surrounding the cavity, using a plurality of barrier-deployment elements coupled at respective distal ends thereof to the barrier device and to the pushing element,

the cavity including a defect in bone tissue,

wherein a first one of the barrier-deployment elements includes a spring, including;

a first spring-arm that is pivotably coupled to the pushing element at a proximal end of the first spring-arm; and

a second spring-arm that is pivotably coupled to the pushing element at a proximal end of the second spring-arm, wherein the proximal end of the second spring-arm is more longitudinally moveable with respect to the pushing element than is the proximal end of the first spring-arm.

19. A method for treating a cavity in a human body using a barrier device having a collapsed configuration and an expanded configuration, the method comprising:

deploying the barrier device from a delivery tube, using a pushing element slidably disposed within a lumen of the delivery tube, the barrier device moving from the collapsed configuration to the expanded configuration upon being deployed; and

conformingly contacting the barrier device with tissue surrounding the cavity, using a plurality of barrier-deployment elements coupled at respective distal ends thereof to the barrier device and to the pushing element,

the cavity including a defect in periodontal tissue,

wherein a first one of the barrier-deployment elements includes a spring, including;

a first spring-arm that is pivotably coupled to the pushing element at a proximal end of the first spring-arm; and

a second spring-arm that is pivotably coupled to the pushing element at a proximal end of the second spring-arm, wherein the proximal end of the second spring-arm is more longitudinally moveable with respect to the pushing element than is the proximal end of the first spring-arm.