Transdermal therapeutic system with pressure generating device

• US 9,895,521 B2
• Filed: 02/12/2016
• Issued: 02/20/2018
• Est. Priority Date: 08/23/2013
• Status: Active Grant

• Current Assignee: LTS Lohmann Therapie-Systeme AG
• Original Assignee: LTS Lohmann Therapie-Systeme AG
• Inventors: Mohr, Patrick
• Primary Examiner(s): Schmidt, Emily
• Assistant Examiner(s): STILES, AMBER R.
• Application Number:
  US15/042,493
• Publication Number:
  US 20160158515A1
• Time in Patent Office: 739 Days
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure

Abstract

A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element.

Claims

1. A transdermal therapeutic system (10) for introducing liquid or liquefiable substance into skin (2) of a patient, including a system support (21) comprising a concave body including a cover part (26) and wall parts (27) adjoining the cover part (26), the cover part (26) and the wall parts (27) in operative arrangement to form a shell (25), an interior (28) of the system support (21) is delimited on five sides by the shell (25), the system support (21) includes a support part (23) including a bearing surface (24) facing toward the skin (2) in an operative position, at least one advancing element (31) is arranged in the interior (28) of the system support (21) and is flush with the bearing surface (24) or it protrudes from the bearing surface (24) in the direction of the skin (2) in the operative position, and at least one active substance reservoir (41) which is elastically deformable at least in some regions and which is embedded into the advancing element (31), wherein, on an application side (11) of the transdermal therapeutic system (10), the shell (25) of the system support (21) surrounds the advancing element (31), and the latter surrounds the active substance reservoir (41), and wherein the advancing element (31) comprises a swelling body (31) which is expanded by liquid uptake, characterized in that the system support (21) is deformation-resistant at least in some regions.

2. The transdermal therapeutic system (10) as claimed in claim 1, characterized in that the active substance reservoir (41) includes hollow micro-needles (45), which connect an interior (46) of the active substance reservoir (41) to the environment (1) on the application side (11).

3. The transdermal therapeutic system (10) as claimed in claim 1, characterized in that the system support (21) comprises an adhesive layer (22) at least on the application side (11).

4. The transdermal therapeutic system (10) as claimed in claim 1, characterized in that the active substance reservoir (41) comprises a liquid or liquefiable active substance formulation (44).

5. The transdermal therapeutic system (10) as claimed in claim 1, characterized in that an intermediate layer (61) is arranged between the swelling body (31) and the active substance reservoir (41).

6. The transdermal therapeutic system (10) as claimed in claim 1, characterized in that at least one hollow needle (33, 34) connects the swelling body (31) to the environment (1) on the application side (11).

7. The transdermal therapeutic system (10) as claimed in claim 6, characterized in that a semipermeable membrane (36) closes the hollow needle (34) on a handling side (12) of the transdermal therapeutic system (10) facing away from the application side (11).

8. The transdermal therapeutic system (10) as claimed in claim 2, characterized in that the micro-needles (45) are at least one of porously soluble and swellable.

9. The transdermal therapeutic system (10) as claimed in claim 2, characterized that an integrated liquid reservoir (71) is operatively arranged in the interior (28) of the system support (21) between the advancing element (31) and the system support (21), the advancing element (31) carries tearing spikes (38) which are initially spaced apart from the integrated liquid reservoir (71) until use of the transdermal therapeutic system (10) wherein the tearing spikes (38) opens the integrated liquid reservoir (71) causing the advancing element (31) to swell and forces an active substance (44) out of the active substance reservoir (41) through the micro-needles (45).