Methods and systems for disease treatment using electrical stimulation
First Claim
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1. A method for treating a patient by changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient, comprising:
- using a signal generator to generate an electrical therapy signal having a frequency in a frequency range of 1.5 kHz to 100 kHz;
transmitting the electrical therapy signal to a signal delivery element positioned proximate to a target neural population located in the patient'"'"'s central nervous system;
applying the electrical therapy signal to the target neural population located in the patient'"'"'s central nervous system, wherein the electrical therapy signalproduces changes in the activity, expression, or both activity and expression of the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell of the patient.
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Abstract
Systems for disease treatment using electrical stimulation are disclosed. A representative method for treating a patient includes changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient by applying to a target neural population of the patient an electrical therapy signal having a frequency in a frequency range of 1.5 kHz to 100 kHz.
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Citations
26 Claims
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1. A method for treating a patient by changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient, comprising:
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using a signal generator to generate an electrical therapy signal having a frequency in a frequency range of 1.5 kHz to 100 kHz; transmitting the electrical therapy signal to a signal delivery element positioned proximate to a target neural population located in the patient'"'"'s central nervous system; applying the electrical therapy signal to the target neural population located in the patient'"'"'s central nervous system, wherein the electrical therapy signal produces changes in the activity, expression, or both activity and expression of the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for treating a patient by changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient, comprising:
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using a signal generator to generate an electrical therapy signal having a frequency in a frequency range of 1.5 kHz to 100 kHz, a pulse width in a pulse width range of 10 microseconds to 333 microseconds and an amplitude in an amplitude range of 0.1 mA to 20 mA; transmitting the electrical therapy signal to a signal delivery element positioned proximate to a target neural population located in the patient'"'"'s central nervous system; applying the electrical therapy signal to the target neural population located in the patient'"'"'s central nervous system, wherein the electrical therapy signal produces changes in the activity, expression, or both activity and expression of the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell of the patient, and wherein the electrical therapy signal treats chronic pain. - View Dependent Claims (22)
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23. A method for treating a patient by changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient, comprising:
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using a signal generator to generate an electrical therapy signal having a pulse width in a pulse width range of 10 microseconds to 333 microseconds; transmitting the electrical therapy signal to a signal delivery element positioned proximate to a target neural population located in the patient'"'"'s central nervous system; applying the electrical therapy signal to the target neural population located in the patient'"'"'s central nervous system, wherein the electrical therapy signal produces changes in the activity, expression, or both activity and expression of the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell of the patient. - View Dependent Claims (24, 25)
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26. A method for treating a patient by changing an activity, expression, or both activity and expression of a fast sodium channel, a glial cell, or both a fast sodium channel and a glial cell of the patient, comprising:
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using a signal generator to generate an electrical therapy signal having a frequency in a frequency range of 1.5 kHz to 100 kHz; transmitting the electrical therapy signal to a signal delivery element positioned proximate to a target neural population located in the patient'"'"'s central nervous system; and applying the electrical therapy signal to the target neural population, wherein the electrical therapy signal produces changes in the activity, expression, or both activity and expression of the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell of the patient, and wherein the target neural population is remote from the fast sodium channel, the glial cell, or both the fast sodium channel and the glial cell.
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Specification