On-demand drug release using magneto-electric nanoparticles
First Claim
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1. A method comprising:
- administering to a subject a plurality of magneto-electric nanoparticles (MENP) having (i) a coating on at least a portion of the MENP surface, said coating one or more of glycerol monooleate, poly L-lysine and polyethylene glycol, and (ii) a drug associated with the MENP through an ionic bond; and
applying a magnetic field to the subject to weaken the ionic bond thereby releasing at least a portion of the drug from the MENP.
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Abstract
Disclosed herein are methods of delivering drugs to a subject in a controlled release fashion by administering a magneto-electric nanoparticle having ionic bonds to a drug then applying a magnetic field to weaken the ionic bonds and release the drug.
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Citations
19 Claims
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1. A method comprising:
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administering to a subject a plurality of magneto-electric nanoparticles (MENP) having (i) a coating on at least a portion of the MENP surface, said coating one or more of glycerol monooleate, poly L-lysine and polyethylene glycol, and (ii) a drug associated with the MENP through an ionic bond; and applying a magnetic field to the subject to weaken the ionic bond thereby releasing at least a portion of the drug from the MENP. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19)
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17. A method comprising:
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administering to a subject a plurality of magneto-electric nanoparticles (MENP) having a coating layer and a drug associated with at least a portion of the surface of the MENP through an ionic bond; and applying a magnetic field to the subject to weaken the ionic bond thereby releasing at least a portion of the drug from the MENP, wherein the coating layer comprises one or more of glycerol monooleate, polyethylene glycol, and poly-L-lysine, and the MENP comprises CoFe2O4@BaTiO3.
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Specification