Long-acting polypeptides and methods of producing same
First Claim
1. A method of extending Cmax of a cytokine comprising the step of attaching one chorionic gonadotropin carboxy terminal peptide (CTP) to the amino terminus of said cytokine and two chorionic gonadotropin carboxy terminal peptides to the carboxy terminus of said cytokine, thereby extending Cmax of said cytokine.
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Abstract
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
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Citations
20 Claims
- 1. A method of extending Cmax of a cytokine comprising the step of attaching one chorionic gonadotropin carboxy terminal peptide (CTP) to the amino terminus of said cytokine and two chorionic gonadotropin carboxy terminal peptides to the carboxy terminus of said cytokine, thereby extending Cmax of said cytokine.
- 8. A pharmaceutical composition comprising a buffer, a tonicity agent, and a polypeptide consisting of a cytokine attached to a single chorionic gonadotropin carboxy terminal peptide (CTP) at the amino terminus of said cytokine, and two chorionic gonadotropin carboxy terminal peptides (CTP) attached to the carboxy terminus of said cytokine.
Specification