Oncolytic rhabdovirus
First Claim
Patent Images
1. An attenuated Maraba virus comprising:
- a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO;
5 and an arginine at the position corresponding to position 242 of SEQ ID NO;
5.
4 Assignments
0 Petitions
Accused Products
Abstract
Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.
-
Citations
21 Claims
-
1. An attenuated Maraba virus comprising:
a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO;
5 and an arginine at the position corresponding to position 242 of SEQ ID NO;
5.- View Dependent Claims (18)
-
2. A method of killing a hyperproliferative cell comprising contacting the cell with an isolated oncolytic Maraba virus encoding:
a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO;
5 and an arginine at the position corresponding to position 242 of SEQ ID NO;
5.- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 19)
-
10. A method for treating a cancer patient comprising administering an effective amount of an isolated oncolytic Maraba virus encoding:
a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO;
5 and an arginine at the position corresponding to position 242 of SEQ ID NO;
5.- View Dependent Claims (11, 12, 13, 20)
-
14. A composition comprising an isolated oncolytic Maraba virus having a nucleic acid segment encoding:
a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO;
5 and an arginine at the position corresponding to position 242 of SEQ ID NO;
5.- View Dependent Claims (15, 16, 17, 21)
Specification