×

Second harmonic imaging nanoprobes and techniques for use thereof

  • US 9,897,587 B2
  • Filed: 10/24/2016
  • Issued: 02/20/2018
  • Est. Priority Date: 11/21/2006
  • Status: Active Grant
First Claim
Patent Images

1. A method of probing structures and biological processes comprising:

  • interspersing a probe nanostructure with a target of interest, such that the probe nanostructure interacts with the target of interest, and wherein the probe nanostructure formed of a crystal material having a unit cell with no inversion symmetry such that it generates a second harmonic emission when radiated by an excitation source;

    radiating the probe nanostructure with an external excitation source such that the crystal material of the probe nanostructure generates a second harmonic emission;

    detecting the second harmonic emission from the nanoprobe; and

    wherein the at least one probe nanostructure generates the second harmonic emission regardless of the attachment and orientation of the probe nanostructure to the target.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×