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Methods for reducing immune responses

  • US 9,901,645 B2
  • Filed: 08/09/2016
  • Issued: 02/27/2018
  • Est. Priority Date: 08/10/2010
  • Status: Active Grant
First Claim
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1. A method for reducing an immune response of a subject to a foreign antigen, comprising:

  • administering a fusion molecule to a subject for reducing an immune response and inducing tolerogenesis, the fusion molecule comprising;

    a foreign antigen comprising an immunogenic gliadin fragment, wherein exposure of the subject to the immunogenic gliadin fragment elicits an immune response by the subject anda cell-binding moiety comprising an antibody fragment fused to the N- or C-terminus of the foreign antigen; and

    wherein said administration is intravenous,wherein an amount effective to reduce an immune response to the foreign antigen is administered,wherein, upon administration the cell binding moiety non-covalently and specifically binds to glycophorin A on the surface of erythrocytes in blood of the subject with a dissociation constant of between about 10 μ

    M and 0.1 nM as determined by equilibrium binding measurements between the cell-binding moiety and erythrocytes and does not specifically bind to other blood components, andwherein the binding of the fusion molecule results in the presentation of the antigen to the immune system of the subject, which downregulates the degree to which the immune system responds to the foreign antigen, thereby reducing the immune response to the foreign antigen.

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