Medical injection device

• US 9,901,683 B2
• Filed: 03/15/2013
• Issued: 02/27/2018
• Est. Priority Date: 04/20/2012
• Status: Expired due to Fees

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Kjeldsen, Bastian G., Mouridsen, Brian
• Primary Examiner(s): Farrar, Lauren P
• Application Number:
  US14/395,652
• Publication Number:
  US 20150065963A1
• Time in Patent Office: 1,810 Days
• CPC Class Codes: A61M 2005/2026 Semi-automatic, e.g. user activated piston is assisted by additional source of energy
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2492 via snap connection
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 2005/3154 limiting maximum permissible dose
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/31501 Means for blocking or restricting the movement of the rod or piston A61M5/5013 takes precedence
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

The present invention relates to an injection device (1) for setting and injecting set doses from a held drug cartridge (10). The injection device (1) comprises a housing (110, 120, 130, 140), a piston rod (800), a rotatable driver (500, 700) and a dose control member (350). A stored energy source (560) is configured to drive rotation of the driver (500, 700) to cause the piston rod (800) to expel a set dose. The dose control member (350) rotates during dose setting and during dose expelling. A first clutch (C1) is arranged between the dose control member (350) and the driver (500, 700). A second clutch (C2) is arranged between the driver (500, 700) and the housing (110, 120, 130, 140) to control the expelling movement. During dose setting the first clutch (C1) is disengaged and the second clutch (C2) is engaged. During dose expelling the first clutch (C1) is engaged and the second clutch (C2) is disengaged.

Claims

1. A medical injection device for setting and injecting set doses from a held drug cartridge, comprising:

a housing defining proximal and distal ends,

a dose setting arrangement including a dose setting device that is moved in a first direction away from a predetermined stop in accordance with the size of a set dose and that moves back to the predetermined stop during injection of the set dose, the predetermined stop being configured for being fixedly arranged relative to the housing,

an injection activator adapted to be activated to inject the set dose,

a piston rod adapted to translate relative to the housing in a distal direction in order to expel a set dose, and

a rotatable driver coupled to the piston rod and including a stored energy source configured to drive rotation of the driver when the injection activator is activated to cause the piston rod to translate relative to the housing, wherein the stored energy source comprises energy sufficient to drive the piston rod for expelling the entire useable contents of the held drug cartridge,

Wherein;

the dose setting device defines a dose control member configured for rotation around a first axis,

a first clutch arrangement is arranged between the dose control member and the driver, wherein the first clutch arrangement is disengaged during dose setting so that the dose control member is disengaged from the driver, and wherein the first clutch arrangement engages by engaging the dose control member with the driver upon activation of the injection activator to enable the driver to rotate the dose control member while causing the dose setting device to move back towards the predetermined stop, and

a second clutch arrangement arranged between the driver and the housing, wherein the second clutch arrangement is engaged during dose setting so that the driver is prevented from rotating during dose setting, and wherein the second clutch arrangement disengages upon activation of the injection activator to enable the driver to rotate relative to the housing.

2. An injection device as defined in claim 1, wherein

the driver defines a drive member arranged for rotation coaxially with the dose control member, the drive member having a first track disposed thereon,

wherein the dose control member has a second track disposed thereon,

wherein an end of content track follower is arranged between the drive member and the dose control member, the end of content track follower being in engagement with the first track and in engagement with the second track, wherein the first track and the second track are configured to cause the end of content track follower to move along the first axis when the dose control member is rotated relative to the drive member, and

wherein the end of content track follower moves towards an end of content stop as the dose setting device is dialled up, the end of content stop being arranged at a predefined position to prevent the dose setting device from being rotated beyond the end of content stop.

3. An injection device as defined in claim 2, wherein during injection of the set dose the first clutch arrangement prevents the drive member from rotating relative to the dose control member.

4. An injection device as defined in claim 2, wherein one of the first track and the second track forms a screw thread and wherein the other one of the first track and the second track forms an axial track.

5. An injection device as defined in claim 2, wherein both first track and second track form screw threads and wherein the lead of the first track is different than the lead of the second track.

6. An injection device as defined in claim 2, wherein at least one of the first track and the second track forms a screw thread and wherein the end of content stop is arranged fixedly relative to the at least one screw thread.

7. An injection device as defined in claim 1, wherein the dose control member is axially moved from an inactivated position and into an activated position upon the injection activator being activated and wherein the axial position of the dose control member controls the first clutch arrangement and the second clutch arrangement.

8. An injection device as defined in claim 1, wherein the injection device comprises a dose setting member coupled to the dose setting device for operating the dose setting device.

9. An injection device as defined in claim 8, wherein a third clutch arrangement is arranged between the dose control member and the dose setting member, wherein the third clutch arrangement is engaged during dose setting so that the dose control member rotates together with the dose setting member, and wherein the third clutch arrangement disengages upon activation of the injection activator to enable the dose control member to rotate independently from the dose setting member.

10. An injection device as defined in claim 9, wherein the axial position of the dose control member controls the third clutch arrangement, and wherein the dose control member is axially moved from an inactivated position and into an activated position upon the injection activator being activated and wherein the axial position of the dose control member controls the first clutch arrangement and the second clutch arrangement.

11. An injection device as defined in claim 1, wherein at least a piston engaging end of the piston rod extends along a second axis, the second axis being offset from the first axis by a distance, wherein the driver comprises a drive nut that rotates around the second axis.

12. An injection device as defined in claim 1, wherein the piston rod is a flexible piston rod having a first end extending in parallel with the second axis and adapted to engage a piston of the held drug cartridge and wherein the second end of the piston rod is adapted to be flexed away from the second axis.

13. An injection device as defined in claim 1, wherein the stored energy source comprises a constant force spring.

14. An injection device as defined in claim 13, wherein the constant force spring is arranged in an s-shaped configuration between the first and the second axis, and wherein at least a piston engaging end of the piston rod extends along a second axis, the second axis being offset from the first axis by a distance, wherein the driver comprises a drive nut that rotates around the second axis.