Apparatus and method for heating a treatment region with an alternating electric field

• US 9,901,742 B2
• Filed: 05/09/2011
• Issued: 02/27/2018
• Est. Priority Date: 05/09/2011
• Status: Active Grant

• Current Assignee: Innovolink, LLC
• Original Assignee: Innovolink, LLC
• Inventors: Marc, Michel
• Primary Examiner(s): Stoklosa, Joseph
• Assistant Examiner(s): AVIGAN, ADAM JOSEPH
• Application Number:
  US13/103,638
• Publication Number:
  US 20120290048A1
• Time in Patent Office: 2,486 Days
• Field of Search: 607 98-102, 607148, 607152, 606 32- 52, 219764-780
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052

Abstract

An apparatus and method for heating a treatment region of a subject via the application of an alternating electric field is disclosed. The method includes positioning a treatment region of a subject between a first electrode and a second electrode sized to extend across the treatment region. The first and second electrodes are connected to a generator operable to apply an alternating electric field between the electrodes at a frequency in the range of 1 MHz to 100 MHz. The method also includes activating the generator to apply the alternating electric field between the first and second electrodes and across the treatment region. The alternating electric field causes movement of polar molecules in the treatment region whereby friction resulting from this molecular movement translates into heat throughout the treatment region.

Claims

1. A method for heating a treatment region of a subject via the application of an alternating electric field, comprising:

positioning a treatment region of a subject between a first high voltage electrode and a second ground electrode, wherein said first electrode is parallel to said second electrode, wherein said treatment region comprises all or a portion of a human body that includes a plurality of cells having at least one specified cell type, and wherein said treatment region has a plurality of thicknesses extending between said first and second electrodes, wherein the plurality of thicknesses comprises a first thickness and a second thickness, wherein the first thickness is greater than the second thickness;

displacing any air located between said treatment region and said first and second electrodes with one or more flowable materials contained within one or more bladders that conform to said treatment region, wherein the first thickness is positioned such that it directly abuts the first and second electrodes, while one or more flowable materials are positioned between the second thickness and the first and second electrodes; and

activating a generator connected to said first and second electrodes, wherein said generator is operable to generate a sinusoidal signal so as to apply an alternating electric field between said first and second electrodes and across said treatment region to thereby heat said treatment region, wherein each flowable material is a mixture of at least two substances having relative concentrations calculated to optimize a dielectric constant and dissipation factor of the mixture and which cause said cells having said specified cell type to heat at a substantially same rate in either the first and second thicknesses and throughout said treatment region between said first and second electrodes.

2. The method of claim 1 wherein said first and second electrodes are sized to extend across said treatment region.

3. The method of claim 1 wherein said alternating electric field causes movement of polar molecules in said treatment region whereby friction resulting from said molecular movement translates into heat throughout said treatment region.

4. The method of claim 1 wherein said alternating electric field is generated at a frequency in the range of 1 MHz to 100 MHz.

5. The method of claim 1 wherein said alternating electric field is generated at a frequency of 27.12 MHz or 40.68 MHz.

6. The method of claim 1 wherein a difference between a voltage provided at a point on said first electrode compared to each of a plurality of additional voltages provided at each of a plurality of additional points on said first electrode is less than ±

10%.

7. The method of claim 6 wherein said signal generated by said generator has a wavelength λ

, and wherein said point on said first electrode is located a distance of ¼

λ

or ¼

λ

plus a multiple of ½

λ

from said single output of said generator.

8. The method of claim 1 wherein a difference between a first current passing between said first and second electrodes and through a first portion of said treatment region compared to each of a plurality of additional currents passing between said first and second electrodes and through each of a plurality of additional portions of said treatment region is less than ±

25%.

9. The method of claim 8 wherein the composition of each flowable material allows said first current and said additional currents to pass between said first and second electrodes and through said treatment region.

10. A method for heating a treatment region of a subject via the application of an alternating electric field, comprising:

positioning a treatment region of a subject comprising a first sub-region and a second sub-region between a first high voltage electrode and a second ground electrode, wherein said first and second electrodes are each sized to extend across said first and second sub-regions, wherein each of said first and second sub-regions comprises a portion of a human body that includes a plurality of cells having at least one specified cell type, wherein said first sub-region has a first thickness extending between said first and second electrodes and said second sub-region has a second thickness extending between said first and second electrodes, wherein said first thickness is less than said second thickness;

displacing any air located between said first and second sub-regions and said first and second electrodes with one or more flowable materials; and

activating a generator connected to said first and second electrodes, wherein said generator is operable to generate a sinusoidal signal so as to apply an alternating electric field between said first and second electrodes and across said first and second sub-regions to thereby heat said first and second sub-regions, wherein each flowable material is a mixture of at least two substances having relative concentrations calculated to optimize a dielectric constant and dissipation factor of the mixture and which cause said cells having said specified cell type to heat at a substantially same rate throughout the first and second thicknesses of said first and second sub-regions, respectively, between said first and second electrodes.

11. The method of claim 10 wherein said alternating electric field causes movement of polar molecules in said sub-regions whereby friction resulting from said molecular movement translates into heat throughout said sub-regions.

12. The method of claim 10 wherein said alternating electric field is generated at a frequency in the range of 1 MHz to 100 MHz.

13. The method of claim 10 wherein said alternating electric field is generated at a frequency of 27.12 MHz or 40.68 MHz.

14. The method of claim 10 wherein a difference between a voltage provided at a point on said first electrode compared to each of a plurality of additional voltages provided at each of a plurality of additional points on said first electrode is less than ±

10%.

15. The method of claim 14 wherein said signal generated by said generator has a wavelength λ

, and wherein said point on said first electrode is located a distance of ¼

λ

or ¼

λ

plus a multiple of ½

λ

from said single output of said generator.

16. The method of claim 10 wherein a difference between a first current passing between said first and second electrodes and through said first sub-region compared to a second current passing between said first and second electrodes and through said second sub-region is less than ±

25%.

17. The method of claim 16 wherein the composition of each flowable material allows said first current and said second current to pass between said first and second electrodes and through said first and second sub-regions, respectively.