Method for preparing a hydrogel through the use of alkoxydes, the product thus obtained and the use thereof

• US 9,902,795 B2
• Filed: 09/17/2007
• Issued: 02/27/2018
• Est. Priority Date: 11/03/2006
• Status: Active Grant

• Current Assignee: Pharmafill SRL
• Original Assignee: Pharmafill SRL
• Inventors: Balestrieri, Gerardo
• Primary Examiner(s): Yoon, Tae H
• Application Number:
  US12/447,555
• Publication Number:
  US 20100099812A1
• Time in Patent Office: 3,816 Days
• Field of Search: 524804, 524 35, 524916, 523105, 525 11, 525 57
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: C08F 16/06 Polyvinyl alcohol ; Vinyl alcohol
• CPC Class Codes: C08F 261/04 on to polymers of vinyl alcohol
• CPC Class Codes: C08F 2810/20 leading to a crosslinking, either explicitly or inherently
• CPC Class Codes: C08F 2810/30 leading to the formation or introduction of aliphatic or alicyclic unsaturated groups
• CPC Class Codes: C08F 8/30 Introducing nitrogen atoms or nitrogen-containing groups
• CPC Class Codes: C08J 2329/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08J 3/075 Macromolecular gels
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

A process for the preparation of a completely biocompatible and reabsorbable hydrogel, through the use of alkoxides of polymers and/or resins containing hydroxyl functions. The invention also relates to the hydrogel obtainable with the method and uses thereof. In particular, the invention relates to the use of the hydrogel for the preparation of an injectable filler for correcting and/or treating different types of tissue deficits.

Claims

1. A method of using a cross-linked hydrogel, said cross-linked hydrogel obtained by a process in which the cross-linked hydrogel is obtained through a reaction step which consists of reacting a hydroxyl function-containing polymer selected from the group consisting of polyvinyl alcohol, polyallyl alcohol, and polyvinylethylene alcohols, with a monomer containing at least two carbon-carbon double bonds selected from the group consisting of bisacrylamides, methylenebisacrylamide, ethylenebisacrylamide, isopropylenebisacrylamide and diallyl urea, in an aqueous basic environment, said method comprising a step of using said hydrogel as an injectable filler for treating a joint tissue deficit.

2. The method according to claim 1, wherein said injectable filler can be injected and patterned in loco after the application.

3. The method according to claim 2, wherein said injectable filler is reabsorbable.

4. The method of claim 1, wherein the hydrogel is free of residual monomers of catalyst.

5. The method of claim 1, wherein the hydrogel is free of residual monomers of collateral reaction products.

6. The method of claim 4, wherein the hydrogel is free of residual monomers of collateral reaction products.

7. The method of claim 1, wherein said injectable filler is effective to be subcutaneously injected as a filler of soft parts.