Non-invasive method and apparatus for determining lung tissue thermal properties and for extra vascular lung water measurement
First Claim
1. A non-invasive method for determining an extravascular lung water volume in a patient, comprising:
- providing a flow meter and a temperature sensor associated with a mouthpiece, and a processor that is part of, or connectable to, the flow meter and temperature sensor;
continuously measuring, with the flow meter, first sensing data and continuously measuring, with the temperature sensor, second sensing data, wherein the first sensing data is indicative of a flow of an inspired and an expired gas at an entrance of a patient'"'"'s upper respiratory tract through the mouthpiece, while a property of said inspired gas or a breathing parameter is controllably changed during said measurements, and wherein the second sensing data is indicative of temperatures of said inspired and said expired gas at the entrance of the patient'"'"'s upper respiratory tract through said mouthpiece during said continuous measurements;
processing said first sensing data to determine time points corresponding to ends of expiration phases during a predetermined number of breathing cycles;
processing the second sensing data to obtain data indicative of a difference between a temperature of said expired gas temperature and a temperature of said inspired gas at said time points corresponding to the ends of the expiration phases;
analyzing said data indicative of the difference to determine a rate of change of the temperature difference, said rate of change being used to determine said extravascular lung water volume; and
generating output data corresponding to said extravascular lung water volume.
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Abstract
The subject matter discloses a noninvasive method and device for detection, measurement and monitoring of Pulmonary Interstitial fluid—Extravascular Lung Water —volumes in inpatient settings: Intensive Care Units, Emergency Rooms, Internal Hospital Departments, and daily monitoring of chronic patient in outpatient settings: outpatient departments, rehab centers and Home monitoring. The disclosed method is based on the analysis of lung tissue thermodynamic properties, and their deviation from normal value. The device measures the rate of temperature change of a lung tissue by measuring the exhaled gas temperature changing rate during cooling/heating of lung tissue. The cooling/heating of lung tissue may be achieved by prompt changing one of the inhaled gas parameters temperature, and/or humidity, and/or rate of breathing, and/or tidal volume, and/or type of gas and etc. The change is performed at the beginning of measurement, and is kept during entire measurement time.
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Citations
8 Claims
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1. A non-invasive method for determining an extravascular lung water volume in a patient, comprising:
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providing a flow meter and a temperature sensor associated with a mouthpiece, and a processor that is part of, or connectable to, the flow meter and temperature sensor; continuously measuring, with the flow meter, first sensing data and continuously measuring, with the temperature sensor, second sensing data, wherein the first sensing data is indicative of a flow of an inspired and an expired gas at an entrance of a patient'"'"'s upper respiratory tract through the mouthpiece, while a property of said inspired gas or a breathing parameter is controllably changed during said measurements, and wherein the second sensing data is indicative of temperatures of said inspired and said expired gas at the entrance of the patient'"'"'s upper respiratory tract through said mouthpiece during said continuous measurements; processing said first sensing data to determine time points corresponding to ends of expiration phases during a predetermined number of breathing cycles; processing the second sensing data to obtain data indicative of a difference between a temperature of said expired gas temperature and a temperature of said inspired gas at said time points corresponding to the ends of the expiration phases; analyzing said data indicative of the difference to determine a rate of change of the temperature difference, said rate of change being used to determine said extravascular lung water volume; and generating output data corresponding to said extravascular lung water volume. - View Dependent Claims (2, 3, 4)
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5. A non-invasive apparatus for measuring extravascular lung water volume in a patient, the apparatus comprising:
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a first sensor [2] configured for continuously measuring a temperature of an inspired gas and a temperature of an expired gas at an entrance of an upper respiratory tract of a patient via a patient'"'"'s mouthpiece, and for generating first sensing data; and a second sensor [3] configured for measuring a flow of the inspired gas and a flow of the expired gas at the entrance of the upper respiratory tract of the patient, via the patient'"'"'s mouthpiece, and for generating second sensing data; and a processing unit configured for; receiving said first sensing data and said second sensing data, while properties of said inspired gas or breathing parameters are controllably changed during said measurements; processing said second sensing data to determine time points corresponding to ends of expiration phases during at least a predetermined number of breathing cycles; processing the first sensing data to obtain data indicative of a difference between a temperature of said expired gas temperature and a temperature of said inspired gas temperature at said time points corresponding to the ends of the expiration phases; analyzing said data indicative of the difference to determine a rate of change of the temperature difference, said rate of change being used to determine said extravascular lung water volume; and generating output data corresponding to said extravascular lung water volume. - View Dependent Claims (6, 7, 8)
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Specification