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Method and/or system for multicompartment analyte monitoring

  • US 9,907,491 B2
  • Filed: 10/22/2012
  • Issued: 03/06/2018
  • Est. Priority Date: 10/25/2011
  • Status: Active Grant
First Claim
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1. A method of using an analyte monitoring system comprising:

  • modeling a latency in transportation of an analyte between first and second physiological compartments;

    compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment, wherein compensating for the latency is based at least in part on a first parameter comprising a ratio of a volume of a plasma or fluid in the second physiological compartment to a volume of a plasma or fluid in the first physiological compartment, and wherein the one or more measurements are obtained based, at least in part, on one or more values of a sensor signal;

    compensating for an attenuation of the concentration of the analyte in the second physiological compartment in estimating the concentration of the analyte in the first physiological compartment, wherein compensating for the attenuation is based at least in part on the first parameter and a second parameter, wherein the second parameter comprises a ratio of a third parameter to a fourth parameter,wherein the third parameter comprises a sum of a rate of cellular uptake of the analyte and a flux rate for analyte transportation from the second physiological compartment to the first physiological compartment, andwherein the fourth parameter comprises a flux rate for analyte transportation from the first physiological compartment to the second physiological compartment, andwherein the estimating of the concentration of the analyte in the first physiological compartment further comprises;

    multiplying an estimated rate of change in the sensor signal by a first coefficient to provide a first product, wherein the first coefficient is based, at least in part, on the first parameter;

    multiplying a first one of the one or more sensor signal values by a second coefficient to provide a second product, wherein the second coefficient is different than the first coefficient and is based, at least in part, on the first and second parameters; and

    combining the first and second products with an attenuation offset to provide an estimate of the concentration of the analyte in the first physiological compartment,wherein the attenuation offset is based, at least in part, on the rate of cellular uptake of the analyte; and

    wherein the method further comprises generating a command to one or more infusion pumps for infusion of insulin, wherein the command is computed based, at least in part, on the estimated concentration of the analyte in the first physiological compartment.

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