Optoelectronic system and apparatus for connection to biological systems

• US 9,907,496 B1
• Filed: 06/25/2014
• Issued: 03/06/2018
• Est. Priority Date: 06/25/2013
• Status: Active Grant

• Current Assignee: National Technology & Engineering Solutions Of Sandia LLC (Honeywell International Inc.)
• Original Assignee: National Technology & Engineering Solutions Of Sandia LLC (Honeywell International Inc.)
• Inventors: Okandan, Murat, Nielson, Gregory N.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/314,176
• Time in Patent Office: 1,350 Days
• Field of Search: None
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/185 Optical shielding, e.g. baffles
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6868 Brain

Abstract

The present invention relates to a biological probe structure, as well as apparatuses, systems, and methods employing this structure. In particular embodiments, the structure includes a hermetically sealed unit configured to receive and transmit one or more optical signals. Furthermore, the structure can be implanted subcutaneously and interrogated externally. In this manner, a minimally invasive method can be employed to detect, treat, and/or assess the biological target. Additional methods and systems are also provided.

Claims

1. Apparatus comprising a biological probe active structure and an optical connector having a proximal end and a distal end, wherein:

the biological probe active structure comprises an implantable hermetically sealed unit and an optically transparent bonding structure that attaches the hermetically sealed unit to the distal end of the optical connector and facilitates an optical connection of the optical connector to the hermetically sealed unit,

the hermetically sealed unit comprises one or more emitters disposed on a substrate, wherein at least one emitter is configured to transmit a target input to a biological target and wherein the target input is a first optical and/or electrical signal;

the hermetically sealed unit further comprises one or more detectors disposed on the substrate, wherein at least one detector is configured to receive a target output from the biological target and wherein the target output is a second optical and/or electrical signal;

the hermetically sealed unit further comprises a signal processor circuitry disposed on the substrate and coupled electrically to the one or more emitters and the one or more detectors;

the hermetically sealed unit further comprises a power component disposed on the substrate and configured to receive external optical power and provide internal electrical power for use by other elements disposed on the substrate;

the optical connector is an optical fiber,

the apparatus further comprises an optical collector connected to the proximal end of the optical fiber; and

the power component is disposed so as to receive the external optical power from the optical fiber through the optically transparent bonding structure.

2. The apparatus of claim 1, wherein the signal processor circuitry is configured to receive one or more electrical signals from at least one detector within the probe active structure, apply an algorithm to the electrical signal(s) to provide one or more processed electrical signals, and transmit the processed electrical signal (a) to at least one emitter within the probe active structure, wherein the emitter(s) is configured to convert the processed electrical signal(s) to one or more optical signals as the target input for transmission to the biological target.

3. The apparatus of claim 1, wherein the biological probe active structure is a self-contained single module configured to be embedded in a target region, and wherein the biological probe active structure is configured to transmit the one or more target inputs directly into the target region and to receive one or more target outputs directly from the same target region.

4. The apparatus of claim 1, further comprising an ionic layer and/or a modulation layer disposed on a peripheral surface of the hermetically sealed unit.

5. The apparatus of claim 4, wherein the ionic layer and/or the modulation layer comprises a light-activated material, an optically interrogatable material, a detection material, or a photo missive material.

6. The apparatus of claim 4, wherein the ionic layer comprises a material configured to alter and/or detect a local ionic concentration upon activation.

7. The apparatus of claim 6, wherein the activation comprises stimulating and/or suppressing cellular activity in the target region.

8. The apparatus of claim 4, wherein the modulation layer comprises a material configured to alter and/or detect a local modulator concentration upon activation.

9. The apparatus of claim 1, comprising:

a plurality of coupling nodes, wherein each coupling node comprises at least one said biological probe active structure, and each coupling node is connected optically to the distal end of the connector.

10. The apparatus of claim 9, wherein the optical connector is configured to transmit an external optical input to the coupling node(s) and to receive one or more relayed optical outputs from the coupling node(s).

11. The apparatus of claim 10, wherein the apparatus comprises two or more optical connectors.

12. The apparatus of claim 11, further comprising a first optical connector that comprises a plurality of first coupling nodes and a second optical connector that comprises a plurality of second coupling nodes, wherein at least one first coupling node is configured to communicate electrically and/or optically with at least one second coupling node.

13. The apparatus of claim 9, wherein the optical collector is a lens configured to receive one or more external optical inputs from an external transceiver unit.

14. The apparatus of claim 13, further comprising a reflector disposed on a surface of the collector.

15. The apparatus of claim 9, wherein the optical connector comprises an internal scattering structure or an optical tap configured to split an external optical input into one or more optical input signals.

16. The apparatus of claim 15, wherein each coupling node is arrayed along the optical connector near the scattering structure or tap, such that a portion of the light incident on each scattering structure or tap is coupled into a corresponding coupling node.

17. The apparatus of claim 9, wherein the collector is configured for in vivo implantation or injection in a target region.

18. The apparatus of claim 17, target region is a subcutaneous region in an organism.

19. The apparatus of claim 18, further comprising an external transceiver unit configured to receive and transmit transcutaneous signals to and from the collector.

20. A system comprising the apparatus of claim 9 and further comprising:

an external transceiver unit configured to transmit one or more external optical inputs to the apparatus via the optical connector and configured to receive one or more injected optical outputs from the apparatus, at least one external optical input being an optical power input received by the one or more power photodetectors for providing internal electrical power for use by other elements disposed on a substrate.

21. The system of claim 20, further comprising a power unit configured to be connected to the external transceiver unit and a processing unit configured to be connected to the power unit.

22. The structure of claim 1, wherein the power component comprises one or more power photodetectors.

23. The structure of claim 22, the power component further comprising a storage element for accumulating energy output by the one or more power photodetectors over a relatively long time interval.

24. A method of detecting and/or treating a biological target, the method comprising:

providing one or more external optical inputs to an apparatus comprising one or more biological probe active structures and an optical fiber having a proximal end and a distal end, and receiving one or more injected optical outputs from the apparatus, wherein;

each biological probe active structure comprises an implantable hermetically sealed unit and an optically transparent bonding structure that attaches the hermetically sealed unit to the distal end of the optical fiber and facilitates an optical connection of the optical fiber to the hermetically sealed unit;

the apparatus comprises a plurality of coupling nodes, wherein each coupling node comprises one or more biological probe active structures and each coupling node is connected optically to the distal end of the optical fiber;

each hermetically sealed unit comprises one or more emitters disposed on a substrate, wherein at least one emitter is configured to transmit a target input to a biological target and wherein the target input is a first optical and/or electrical signal;

each hermetically sealed unit further comprises one or more detectors disposed on the substrate, wherein at least one detector is configured to receive a target output from the biological target and wherein the target output is a second optical and/or electrical signal;

each hermetically sealed unit comprises a signal processing circuitry disposed on the substrate and coupled electrically to the one or more emitters and the one or more detectors;

each hermetically sealed unit comprises one or more power photodetectors disposed on the substrate;

the apparatus further comprises an optical collector connected to the proximal end of the optical fiber;

and wherein the providing one or more external optical inputs to the apparatus comprises using an external transceiver unit to transmit the one or more external optical inputs to the apparatus via the optical collector and the optical fiber;

and wherein the receiving one or more injected optical outputs from the apparatus comprises using the external transceiver unit to receive the one or more injected optical outputs from the apparatus;

and wherein the providing one or more external optical inputs to the apparatus further comprises providing, on at least one external optical input, an optical power input received by the one or more power photodetectors from the optical fiber through an optically transparent bonding structure for providing internal electrical power for use by other elements disposed on the substrate.

25. The method of claim 24, further comprising receiving one or more injected optical outputs transmitted from the apparatus.

26. The method of claim 25, wherein an external transceiver unit is configured to transmit the external optical input(s) to the apparatus and to receive the injected optical output(s) from the apparatus.