Analyte sensor

• US 9,907,497 B2
• Filed: 10/18/2013
• Issued: 03/06/2018
• Est. Priority Date: 07/02/2009
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Boock, Robert J., Kamath, Apurv Ullas, Wightlin, Matthew D., Estes, Michael J.
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US14/057,720
• Publication Number:
  US 20140046148A1
• Time in Patent Office: 1,600 Days
• Field of Search: 600318, 600345, 600347, 600364
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0209 Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B05C 3/02 the work being immersed in the liquid or other fluent material
• CPC Class Codes: B05C 3/10 the articles being moved through the liquid or other fluent material conveying articles through baths B65G, e.g. B65G49/02
• CPC Class Codes: B05C 3/125 the work being a web, band, strip or the like
• CPC Class Codes: B05C 5/0241 for applying liquid or other fluent material to elongated work, e.g. wires, cables, tubes
• CPC Class Codes: B05D 1/18 performed by dipping
• CPC Class Codes: B05D 3/06 by exposure to radiation B05D3/02 takes precedence ; plasma treatment B05D3/141
• CPC Class Codes: B23K 26/0823 Devices involving rotation of the workpiece
• CPC Class Codes: B23K 26/362 Laser etching
• CPC Class Codes: B29C 2791/009 Using laser
• CPC Class Codes: C23C 2/00 : Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor

Abstract

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

Claims

1. A sensor system for continuous measurement of a glucose concentration in a host, the sensor system comprising:

a first sensor configured to be implanted in a host and configured to continuously measure a glucose concentration and generate a first signal, wherein the first sensor is associated with a first sensor accuracy during a first time period of a sensor session;

a second sensor configured to be implanted in the host and configured to continuously measure a glucose concentration and generate a second signal, wherein the second sensor is associated with a second sensor accuracy during the first time period of the sensor session; and

sensor electronics configured to determine a glucose concentration value based on at least one of the first or the second signal, wherein the sensor electronics are configured to integrate the first signal and the second signal by providing a distribution of weights associated with the first signal and the second signal and by according a first weight to the first signal and according a second weight to the second signal, wherein the distribution of weights among the first and second sensors is a function of time associated with the initiation of the sensor session.

2. The sensor system of claim 1, wherein the first sensor and the second sensor are both configured to generate a signal during a second time period, wherein the first time period corresponds to an initial period of in vivo implantation, wherein the second time period corresponds to a second time period of in vivo implantation, and wherein the second period begins after the initial period of in vivo implantation has begun.

3. The sensor system of claim 2, wherein the first time period and the second time period overlap partially, but not completely.

4. The sensor system of claim 2, wherein the first time period and the second time period do not overlap.

5. The sensor system of claim 2, wherein the first time period begins before less than 3 hours post-implantation, and wherein the second time period begins after more than 3 hours post-implantation.

6. The sensor system of claim 2, wherein the first time period begins before less than 6 hours post-implantation, and wherein the second time period begins after more than 6 hours post-implantation.

7. The sensor system of claim 1, wherein at least one of the first sensor or the second sensor is configured for transcutaneous placement through a skin of a host.

8. The sensor system of claim 1, wherein the sensor system is configured for fluid communication with a vascular system of a host.

9. A method for processing data from a sensor system configured for continuous measurement of a glucose concentration in a host, the method comprising:

receiving a first signal indicative a glucose concentration in a host from a first sensor;

receiving a second signal indicative of a glucose concentration in the host from a second sensor; and

determining during a sensor session, using sensor electronics, a glucose concentration value based on at least one of the first signal or the second signal, wherein determining the glucose concentration value comprises integrating the first signal and the second signal, wherein integrating the first signal and the second signal comprises according a first weight to the first signal and according a second weight to the second signal, and wherein a magnitude of the first weight and a magnitude of the second weight are a function of time associated with an initiation of the sensor session.

10. The method of claim 9, wherein the sensor session comprises a first time period and a second time period.

11. The method of claim 10, wherein the first time period corresponds to an initial period of in vivo implantation, wherein the second time period corresponds to a second time period of in vivo implantation, and wherein the second period begins after the initial period of in vivo implantation has begun.

12. The method of claim 10, wherein the first time period and the second time period overlap partially, but not completely.

13. The method of claim 10, wherein the first time period and the second time period do not overlap.

14. The method of claim 10, wherein the first time period begins before less than 3 hours post-implantation, and wherein the second time period begins after more than 3 hours post-implantation.

15. The method of claim 10, wherein the first time period begins before less than 6 hours post-implantation, and wherein the second time period begins after more than 6 hours post-implantation.

16. The method of claim 9, wherein at least one of the first sensor or the second sensor is configured for transcutaneous placement through a skin of a host.