Implantable electrochemical biosensor system and method
First Claim
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1. An implantable electrochemical sensor system comprising:
- a biosensor comprising an electrode and a polymer layer containing an enzyme;
a controller for first applying a potential (V) to the biosensor when the biosensor is in contact with a solution, wherein the applied potential is sufficient to oxidize or reduce a redox active species in the solution and generate a current, and then switching off the applied potential;
a potentiometer that measures a plurality of V versus time (t) data points after the switching off of the applied potential; and
a data processor that determines the slope (k) of a plot of V versus 1/√
t, and provides an indication of the thickness of the polymer layer of the biosensor based on the determined slope.
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Abstract
Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.
19 Citations
10 Claims
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1. An implantable electrochemical sensor system comprising:
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a biosensor comprising an electrode and a polymer layer containing an enzyme; a controller for first applying a potential (V) to the biosensor when the biosensor is in contact with a solution, wherein the applied potential is sufficient to oxidize or reduce a redox active species in the solution and generate a current, and then switching off the applied potential; a potentiometer that measures a plurality of V versus time (t) data points after the switching off of the applied potential; and a data processor that determines the slope (k) of a plot of V versus 1/√
t, and provides an indication of the thickness of the polymer layer of the biosensor based on the determined slope. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification