Polymer composites for biomedical applications and methods of making

• US 9,907,556 B2
• Filed: 06/19/2014
• Issued: 03/06/2018
• Est. Priority Date: 06/05/2003
• Status: Active Grant

• Current Assignee: Dfine Incorporated (Merit Medical Systems, Inc.)
• Original Assignee: Dfine Incorporated (Merit Medical Systems, Inc.)
• Inventors: Truckai, Csaba
• Primary Examiner(s): FOWLER, DANIEL WAYNE
• Application Number:
  US14/309,248
• Publication Number:
  US 20140371734A1
• Time in Patent Office: 1,356 Days
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61B 2017/12072 the heat created by laser light
• CPC Class Codes: A61B 2018/00416 Treatment of aneurisms
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: D04H 1/42 characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
• CPC Class Codes: Y10T 428/249924 Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity

Abstract

A biomedical polymer composite that exhibits ultra-low thermal conductivity properties. In a preferred embodiment, the biomedical polymer composite comprises a base polymer component with a dispersed thermally non-conductive filler component consisting of glass or ceramic nanospheres or microspheres that have a thermal conductivity of less than 5 W/m-K, and preferably less than 2 W/m-K. In one embodiment, the polymer composite has an electrically conductive filler and can be used in a filament for treating arteriovascular malformations. In another embodiment, the polymeric composite can be used as an energy-coupling means to apply energy to tissue.

Claims

1. An apparatus for thermally treating tissue, comprising:

an elongate introducer having a proximal end, a distal end, and an interior passageway extending from the proximal end to an opening in the distal end;

a flowable insulative material carried in or otherwise in fluid communication with the interior passageway;

at least one electrode coupled to or proximate to the distal end of the introducer;

an energy delivery actuator configured to controllably energize the at least one electrode; and

a flow actuator configured to actuate a controlled flow of the flowable insulative material from the interior passageway through the distal end opening and outwardly from the distal end of the introducer;

wherein the flowable insulative material comprises a base polymer and dispersed nonconductive filler.

2. The apparatus of claim 1, wherein the flow actuator comprises a member configured for pushing the flowable insulative material through the interior passageway.

3. The apparatus of claim 1, wherein the energy delivery actuator comprises a switch.

4. The apparatus of claim 1, wherein the flow actuator and energy delivery actuator are operatively coupled with one another and configured to operate in unison.

5. The apparatus of claim 4, wherein the flow actuator and energy delivery actuator are operatively coupled to a same actuating switch mechanism.

6. The apparatus of claim 5, further comprising a handle coupled to the proximal end of the elongate introducer, wherein the actuating switch mechanism comprising a trigger coupled to the handle.

7. A system for thermally treating tissue, the system including the apparatus of claim 1, and further comprising a respective power generator and controller operatively coupled to the at least one electrode.

8. The system of claim 1, wherein the nonconductive filler comprises hollow microspheres.

9. The system of claim 1, wherein the base polymer and nonconductive filler comprise bio-absorbable materials.

10. The system of claim 1, wherein the base polymer is selected from the group consisting of:

polyamide, polycarbonate, polystyrene, polyacrylonitrile, polyacetal, thermoplastic modified cellulose, polysulfone, thermoplastic polyester, PET, poly(ethyl acrylate), poly(methyl methacrylate), nylon, fluoropolymer, polyvinylidene fluoride, and ethylene tetrafluoroethylene.

11. The system of claim 1, wherein the flowable insulative material has a thermal conductivity of less than about 5 W/m-K.

12. An apparatus for thermally treating tissue, comprising:

an elongate introducer having a proximal end, a distal end, and an interior passageway extending from the proximal end to an opening in the distal end;

a flowable insulative material carried in or otherwise in fluid communication with the interior passageway;

at least one electrode coupled to or proximate to the distal end of the introducer;

an energy delivery actuator configured to controllably energize the at least one electrode; and

a flow actuator configured to actuate a controlled flow of the flowable insulative material from the interior passageway through the distal end opening and outwardly from the distal end of the introducer;

wherein the flowable insulative material comprises a thermochromic material.

13. A system for thermally treating tissue, comprising:

an elongate introducer having a proximal end, a distal end, a first interior passageway extending from the proximal end to a first opening in the distal end, and a second interior passageway extending from the proximal end to a second opening in the distal end proximate the first opening,

a flowable insulative material carried in or otherwise in fluid communication with the first interior passageway;

a flowable conductive material carried in or otherwise in fluid communication with the second interior passageway;

one or more actuation mechanisms configured to simultaneously actuate a controlled flow of the flowable insulative material out the first distal end opening, and a controlled flow of the flowable conductive material out the second distal end opening; and

at least one electrode coupled to or proximate to the distal end of the introducer; and

an energy delivery actuator configured to controllably energize the at least one electrode;

wherein the flowable insulative material comprises a base polymer and dispersed nonconductive filler.

14. The system of claim 13, wherein the respective one or more actuation mechanisms and the first and second distal end openings are configured such that the respective flowable insulative material and flowable conductive material are simultaneously ejected out the respective first and second distal end openings and flow alongside one another outwardly from the distal end of the elongate introducer.

15. The system of claim 13, wherein the flowable insulative material has a thermal conductivity of less than about 5 W/m-K.

16. The system of claim 13, wherein the flowable insulative material comprises a thermochromic material.