Radiation applicator and method of radiating tissue

• US 9,907,613 B2
• Filed: 11/13/2015
• Issued: 03/06/2018
• Est. Priority Date: 07/01/2005
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Cronin, Nigel, Boix, Maria J
• Primary Examiner(s): HUPCZEY, JR, RONALD JAMES
• Application Number:
  US14/940,354
• Publication Number:
  US 20160262832A1
• Time in Patent Office: 844 Days
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00029 open
• CPC Class Codes: A61B 2018/00077 high, i.e. electrically conducting
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00178 Electrical connectors
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/1838 Dipole antennas
• CPC Class Codes: A61B 2018/1869 with an instrument interstitially inserted into the body, e.g. needles
• CPC Class Codes: A61B 2018/1892 Details of electrical isolations of the antenna
• CPC Class Codes: A61N 5/045 specially adapted for treatment inside the body
• CPC Class Codes: G06T 7/30 Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

A dipole microwave applicator emits microwave radiation into tissue to be treated. The applicator is formed from a thin coax cable having an inner conductor surrounded by an insulator, which is surrounded by an outer conductor. A portion of the inner conductor extends beyond the insulator and the outer conductor. A ferrule at the end of the outer conductor has a step and a sleeve that surrounds a portion of the extended inner conductor. A tuning washer is attached to the end of the extended inner conductor. A dielectric tip encloses the tuning washer, the extended inner conductor, and the sleeve of the ferrule. The sleeve of the ferrule and the extended inner conductor operate as the two arms of the dipole microwave antenna. The tuning washer faces the step in the ferrule, and is sized and shaped to cooperate with the step in balancing and tuning the applicator.

Claims

1. A method of treating tissue, the method comprising:

inserting into the body a radiation applicator for applying electromagnetic radiation to tissue, the radiation applicator comprising;

a central conductor having a distal end and a proximal end, an outer conductor having a distal end and a proximal end, the outer conductor also having an inner surface and an outer surface;

an outer tube having a proximal end and a distal portion, the distal portion including a distal most end, the outer tube also having an inner surface and an outer surface, the distal most end of the outer tube ending proximal to a distal most end of the applicator, the outer tube coaxially surrounding the outer conductor such that a gap is formed between the outer surface of the outer conductor and the inner surface of the outer tube;

a dielectric tip member;

a ferrule having a proximal end and a distal end portion including a distal most end, the distal most end of the ferrule extending distally beyond the distal most end of the outer tube for a selected distance, the ferrule having a first surface, second surface, and a third surface, the first surface of the ferrule extending coaxially along the outer conductor and the central conductor, the second surface of the ferrule coaxially extends between the distal end of the outer conductor and the distal end of the outer tube, and the third surface of the ferrule coaxially extends along the distal end of the central conductor, the ferrule is spaced between the outer conductor and the outer tube thereby sealing the gap such that the proximal end of the ferrule prevents a cooling fluid from contacting a dipole antenna;

a tuning conductor attached to the distal end of the central conductor, the tuning conductor is in electrical contact with the central conductor; and

a dipole antenna formed by the tuning conductor and the dielectric tip member, the dipole antenna configured to radiate electromagnetic energy in at least a radial direction from the dielectric tip member;

placing the dielectric tip in the tissue to be treated;

powering on the energy source;

delivering the energy to the tissue; and

withdrawing the radiation applicator.

2. The method of claim 1, wherein the radiation applicator further comprises the first surface of the ferrule being proximal to the second surface of the ferrule and the second surface of the ferrule being proximal to the third surface of the ferrule.

3. The method of claim 1, wherein the radiation applicator further comprises an insulator coaxially extending between the central conductor and outer conductor, the insulator extending a selected distance beyond the distal most end of the outer conductor.

4. The method of claim 2, wherein the radiation applicator further comprises a proximal most end of the ferrule is a selected distance proximal to the distal most end of the outer conductor.

5. The method of claim 1, wherein the radiation applicator further comprises a tuning conductor received by an abutment wall of the distal end of the central conductor.

6. The method of claim 5, wherein the tuning conductor of the radiation applicator is a metal washer.

7. The method of claim 1, wherein the radiation applicator further comprises a connector for connecting the applicator to an energy source.

8. The method of claim 1, wherein the radiation applicator further comprises an antenna that is capable of creating a frequency of up to 8 GHz.

9. The method of claim 1, wherein the target tissue being treated is a tumor or other soft tissue.

10. A method of treating tissue, the method comprising:

inserting into the body a radiation applicator for applying electromagnetic radiation to tissue, the radiation applicator comprising;

a central conductor having a distal end and a proximal end, an outer conductor having a distal end and a proximal end, the outer conductor also having an inner surface and an outer surface;

an outer tube having a proximal end and a distal portion, the distal portion including a distal most end, the outer tube also having an inner surface and an outer surface, the distal most end of the outer tube ending proximal to a distal most end of the applicator, the outer tube coaxially surrounding the outer conductor such that a gap is formed between the outer surface of the outer conductor and the inner surface of the outer tube;

a dielectric tip member;

a ferrule having a proximal end and a distal end portion including a distal most end, the distal most end of the ferrule extending distally beyond the distal most end of the outer tube for a selected distance, the ferrule having a first surface, second surface, and a third surface, the first surface of the ferrule extending coaxially along the outer conductor and the central conductor, the second surface of the ferrule coaxially extends between the distal end of the outer conductor and the distal end of the outer tube, and the third surface of the ferrule coaxially extends along the distal end of the central conductor, the ferrule is spaced between the outer conductor and the outer tube thereby sealing the gap such that the proximal end of the ferrule prevents a cooling fluid from contacting a dipole antenna;

a tuning conductor attached to the distal end of the central conductor, the tuning conductor is in electrical contact with the central conductor; and

a dipole antenna formed by the tuning conductor and the dielectric tip member, the dipole antenna configured to radiate electromagnetic energy in at least a radial direction from the dielectric tip member;

placing the dielectric tip in the tissue to be treated;

flowing fluid through the gap but not beyond the ferrule;

powering on the energy source;

delivering the energy to the tissue; and

withdrawing the radiation applicator.

11. The method of claim 10, wherein the applicator further comprises the first surface of the ferrule being proximal to the second surface of the ferrule and the second surface of the ferrule being proximal to the third surface of the ferrule.

12. The method of claim 11, wherein the applicator further comprises a proximal most end of the ferrule being a selected distance proximal to the distal most end of the outer conductor.

13. The method of claim 10, wherein the flowing fluid step further comprises:

a fluid conduit connected to a source of fluid via a pumping device, the pumping device flows fluid at a predetermined rate.

14. The method of claim 13, wherein the flowing fluid step further comprises fluid being pumped so as to provide a flow rate of at least 1.5 ml/minute.

15. The method of claim 13, wherein the flowing fluid step further comprises the fluid being at room temperature or pre-cooled to a temperature below room temperature.

16. The method of claim 13, wherein the flowing fluid step further comprises flow of fluid being stopped proximate to the dipole antenna.

17. The method of claim 10, wherein the radiation applicator further comprises a tuning conductor received by an abutment wall of the distal end of the central conductor.

18. The method of claim 10, wherein the radiation applicator further comprises a connector for connecting the applicator to an energy source.

19. The method of claim 10, wherein the radiation applicator further comprises an antenna that is capable of creating a frequency of up to 8 GHz.

20. The method of claim 10, wherein the target tissue being treated is a tumor or other soft tissue.