Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
First Claim
1. A method for delivering PTH or PTH analogue to a patient, the method comprising:
- providing a solid PTH or PTH analogue dosage shaped as a tissue penetrating member; and
penetrating the solid dosage PTH or PTH analogue into an intestinal wall after oral ingestion, wherein PTH or PTH analogue is released into the blood stream from the solid dosage PTH or PTH analogue in the intestinal wall by degradation of the tissue penetrating member,wherein penetrating the solid dosage PTH or PTH analogue into the intestinal wall comprises operably coupling the solid dosage PTH or PTH analogue to a delivery means having a first configuration wherein the solid dosage PTH or PTH analogue is within the capsule and a second configuration wherein the solid dosage PTH or PTH analogue is advanced out of the capsule and into the intestinal wall,wherein the solid dosage PTH or PTH analogue comprise a biodegradable material which degrades within the intestinal wall to release PTH or PTH analogue into the blood stream, andwherein the solid dosage PTH or PTH analogue produces a long-term release of PTH or PTH analogue.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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Citations
18 Claims
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1. A method for delivering PTH or PTH analogue to a patient, the method comprising:
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providing a solid PTH or PTH analogue dosage shaped as a tissue penetrating member; and penetrating the solid dosage PTH or PTH analogue into an intestinal wall after oral ingestion, wherein PTH or PTH analogue is released into the blood stream from the solid dosage PTH or PTH analogue in the intestinal wall by degradation of the tissue penetrating member, wherein penetrating the solid dosage PTH or PTH analogue into the intestinal wall comprises operably coupling the solid dosage PTH or PTH analogue to a delivery means having a first configuration wherein the solid dosage PTH or PTH analogue is within the capsule and a second configuration wherein the solid dosage PTH or PTH analogue is advanced out of the capsule and into the intestinal wall, wherein the solid dosage PTH or PTH analogue comprise a biodegradable material which degrades within the intestinal wall to release PTH or PTH analogue into the blood stream, and wherein the solid dosage PTH or PTH analogue produces a long-term release of PTH or PTH analogue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification