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Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

  • US 9,907,747 B2
  • Filed: 06/29/2016
  • Issued: 03/06/2018
  • Est. Priority Date: 12/23/2010
  • Status: Active Grant
First Claim
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1. A method for delivering PTH or PTH analogue to a patient, the method comprising:

  • providing a solid PTH or PTH analogue dosage shaped as a tissue penetrating member; and

    penetrating the solid dosage PTH or PTH analogue into an intestinal wall after oral ingestion, wherein PTH or PTH analogue is released into the blood stream from the solid dosage PTH or PTH analogue in the intestinal wall by degradation of the tissue penetrating member,wherein penetrating the solid dosage PTH or PTH analogue into the intestinal wall comprises operably coupling the solid dosage PTH or PTH analogue to a delivery means having a first configuration wherein the solid dosage PTH or PTH analogue is within the capsule and a second configuration wherein the solid dosage PTH or PTH analogue is advanced out of the capsule and into the intestinal wall,wherein the solid dosage PTH or PTH analogue comprise a biodegradable material which degrades within the intestinal wall to release PTH or PTH analogue into the blood stream, andwherein the solid dosage PTH or PTH analogue produces a long-term release of PTH or PTH analogue.

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