Use of novel monosaccharide-like glycylated sugar alcohol compositions for designing and developing anti-diabetic drugs

• US 9,907,773 B2
• Filed: 03/18/2016
• Issued: 03/06/2018
• Est. Priority Date: 01/26/2014
• Status: Active Grant

• Current Assignee: Wjwu & Lynn Institute For Stem Cell Research
• Original Assignee: Wjwu & Lynn Institute For Stem Cell Research
• Inventors: Lin, Shi-Lung, Chang-Lin, Samantha, Lin, Yi-Wen, Chang, Donald
• Primary Examiner(s): SCHULTZ, JAMES
• Application Number:
  US15/074,321
• Publication Number:
  US 20160220525A1
• Time in Patent Office: 718 Days
• Field of Search: None
• CPC Class Codes: A61K 31/221 with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• CPC Class Codes: A61K 31/7012 Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid gluconic acid A61K31/191; ascorbic acid A61K31/375
• CPC Class Codes: A61K 31/7024 Esters of saccharides
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: C12N 15/111 General methods applicable to biologically active non-coding nucleic acids
• CPC Class Codes: C12N 15/113 Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing when used in plants C12N15/8218
• CPC Class Codes: C12N 2310/141 MicroRNAs, miRNAs
• CPC Class Codes: C12N 2320/32 Special delivery means, e.g. tissue-specific
• CPC Class Codes: C12N 2330/50 Biochemical production, i.e. in a transformed host cell
• CPC Class Codes: C12N 2330/51 Specially adapted vectors

Abstract

This invention is related to a novel sugar-like chemical composition and its use for diabetes therapy. Particularly, the present invention teaches the use of monosaccharide-like glycylated sugar alcohol compounds to block or reduce sugar absorption in diabetes patients, so as to prevent the risk of hyperglycemia symptoms. Glycylation of sugar alcohols is a totally novel reaction that has never been reported before. Therefore, the novelty of the present invention is that for the first time glycylated sugar alcohols not only was found but also was found to be useful for treating Diabetes mellitus. In addition, the present invention teaches a method for producing these glycylated sugar alcohols. In sum, the present invention includes not only a kind of novel sugar-like chemical compositions and its use for treating diabetes but also a state-of-the-art protocol and methodology for producing such a novel composition via glycylation of sugars and sugar alcohols.

Claims

1. A method for treating the hyperglycemia symptoms and obesity problems of diabetes mellitus, comprising administering a composition comprising a glycylated sugar alcohol or a glycylated sugar to a subject suffering from hyperglycemia symptoms or obesity problems of diabetes mellitus, wherein the glycylated sugar alcohol or the glycylated sugar comes from at least one sugar alcohol or at least one sugar modified by the reaction of glycylation;

wherein the at least one sugar alcohol has a formula of H(HCHO)_n+1H, and the at least one sugar has a formula of H(HCHO)_nHCO,

wherein the composition comprising said glycylated sugar alcohol or said glycylated sugar contains monoglycylglycerol (MGG).

2. The method as defined in claim 1, wherein said glycylation is a chemical reaction in that at least one hydroxyl (—

OH) group of the sugar alcohol or the sugar is replaced by at least one glycyl (NH₃⁺CH₂COO—

) group from a glycine or a glycylated amino acid and results in formation of an ether (R—

O—

R) linkage between each OH-removed carbon of the sugar alcohol or the sugar and each of the glycyl groups.

3. The method as defined in claim 1, wherein said sugar alcohol is glycerol or said sugar is fructose.

4. The method as defined in claim 1, wherein said monoglycylglycerol has a chemical formula of NH₃⁺CH₂CO(HCHO)₃H.

5. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is positively charged.

6. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is administered orally.

7. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is further in solution and has a concentration ranged from 0.1 μ

M to 10 M.

8. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar competes with monosaccharides for intestinal absorption in vivo.

9. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar interferes with sugar absorption in intestines.

10. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is absorbed into cells via glucose transporters.

11. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is a food supplement.

12. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar reduces glucose absorption in vivo and prevents the hyperglycemia symptoms and the obesity problems of diabetes mellitus.

13. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is a part of an active ingredient in the preparation of anti-diabetic drugs.

14. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is a part of an active ingredient in the preparation of anti-obesity drugs.

15. The method as defined in claim 1, wherein said glycylated sugar alcohol or said glycylated sugar is a part of an active ingredient in the preparation of substances for cosmetic, pharmaceutical and therapeutic applications.