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First Claim
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1. An embolic composition comprising:
- embolic particles including a reaction product of a prepolymer solution including at least one macromer and at least one monomer,wherein the at least one macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof,wherein the embolic particles include acidic groups that are treated with an acidic solution to form treated embolic particles,wherein the treated embolic particles have a first diameter and a second diameter, and wherein the second diameter is larger than the first diameter when the treated polymer particle is subjected to a physiological condition, andwherein the embolic particles are substantially spherical, andwherein the first diameter is between about 50 μ
m and about 1,500 μ
m.
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Abstract
Embolic particles are described comprising a treated polymer particle. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. The treated polymer particles can have a first diameter that is smaller than a second diameter, wherein the second diameter is achieved when the treated polymer particle is subjected to a physiological condition. Methods of making and using these polymer particles are also described.
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Citations
17 Claims
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1. An embolic composition comprising:
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embolic particles including a reaction product of a prepolymer solution including at least one macromer and at least one monomer, wherein the at least one macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof, wherein the embolic particles include acidic groups that are treated with an acidic solution to form treated embolic particles, wherein the treated embolic particles have a first diameter and a second diameter, and wherein the second diameter is larger than the first diameter when the treated polymer particle is subjected to a physiological condition, and wherein the embolic particles are substantially spherical, and wherein the first diameter is between about 50 μ
m and about 1,500 μ
m. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of making polymer particles comprising:
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treating polymer particles formed by reacting a prepolymer solution including at least one macromer, an acrylic monomer, and an initiator in non-solvent to form treated polymer particles; wherein the treated polymer particle has a first diameter and a second diameter, wherein the second diameter is larger than the first diameter when the treated polymer particle is subjected to a physiological condition, wherein the at least one macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof, wherein the embolic particles are substantially spherical, and wherein the first diameter is between about 50 μ
m and about 1,500 μ
m. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification