Methods and systems for modulating medicants using acoustic energy
First Claim
1. A system for steering a medicant through a tissue, the tissue having a first region located at a first depth and a second region adjacent to the first region and located at a second depth, the system comprising:
- a probe configured to output a first acoustic energy and a second acoustic energy; and
a control system coupled to the probe and having a control logic configured to control the output of acoustic energy from the probe, the probe and the control system configured to, in use when the medicant is present in the first region, focus the first acoustic energy from the source to the first region, the first acoustic energy having a first spatial and temporal energy profile configured to provide cavitation and radiation force, the cavitation and radiation force configured to move the medicant from the first region to the second region, the probe and the control system further configured to, in use when the medicant has moved from the first region to the second region, focus the second acoustic energy from the source to the second region, the second acoustic energy having a second spatial and temporal energy profile configured to enhance effectiveness of the medicant in the second region.
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Accused Products
Abstract
This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
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Citations
20 Claims
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1. A system for steering a medicant through a tissue, the tissue having a first region located at a first depth and a second region adjacent to the first region and located at a second depth, the system comprising:
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a probe configured to output a first acoustic energy and a second acoustic energy; and a control system coupled to the probe and having a control logic configured to control the output of acoustic energy from the probe, the probe and the control system configured to, in use when the medicant is present in the first region, focus the first acoustic energy from the source to the first region, the first acoustic energy having a first spatial and temporal energy profile configured to provide cavitation and radiation force, the cavitation and radiation force configured to move the medicant from the first region to the second region, the probe and the control system further configured to, in use when the medicant has moved from the first region to the second region, focus the second acoustic energy from the source to the second region, the second acoustic energy having a second spatial and temporal energy profile configured to enhance effectiveness of the medicant in the second region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for delivering a medicant to a region of interest within a tissue, the tissue having a first region located at a first depth, the region of interest located adjacent to the first region and at a second depth, the system comprising:
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a probe configured to output a first acoustic energy and a second acoustic energy; and a control system coupled to the probe and having a control logic configured to control the output of acoustic energy from the probe, the probe and the control system configured to, in use when a medicant is present in the first region, focus the first acoustic energy from the source to the first region, the first acoustic energy having a first spatial and temporal energy profile configured to provide cavitation and radiation force, the cavitation and radiation force configured to move the medicant from the first region to the second region, the probe and the control system further configured to, in use when the medicant has moved from the first region to the region of interest, focus the second acoustic energy from the source to the region of interest, the second acoustic energy having a second spatial and temporal energy profile configured to provide a thermal effect that enhances the effectiveness of the medicant in the region of interest. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A system for delivering a medicant to a portion of skin beneath a stratum corneum, the system comprising:
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a probe configured to output a first acoustic energy and a second acoustic energy; and a control system coupled to the probe and having a control logic configured to control the output of acoustic energy from the probe, the probe and the control system configured to, in use when a medicant is present on a surface of the stratum corneum, focus the first acoustic energy from the source to a first depth beneath the stratum corneum, the first acoustic energy having a first spatial and temporal energy profile configured to provide a first cavitation and radiation force, the first cavitation and radiation force configured to deliver the medicant across the stratum corneum to the first depth beneath the stratum corneum, the probe and the control system further configured to, in use when the medicant has been delivered to the first depth beneath the stratum corneum, focus the second acoustic energy from the source to a second depth beneath the stratum corneum, the second acoustic energy having a second spatial and temporal energy profile configured to provide a second cavitation and radiation force, the second cavitation and radiation force configured to move the medicant from the first depth to the second depth, and wherein the second spatial and temporal energy profile is different from the first spatial and temporal enemy profile. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification