High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
First Claim
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1. A method comprising:
- applying an electrical stimulation to a portion of a spinal cord of a neurologically paralyzed patient in conjunction with physical training of a paralyzed portion of the neurologically paralyzed patient, andadministering one or more neuropharmaceutical agents to the neurologically paralyzed patient,wherein the electrical stimulation is below an amount that fully activates a spinal circuit such that the spinal circuit is at least partially activatable by the addition of supraspinal signals.
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Abstract
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.
224 Citations
20 Claims
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1. A method comprising:
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applying an electrical stimulation to a portion of a spinal cord of a neurologically paralyzed patient in conjunction with physical training of a paralyzed portion of the neurologically paralyzed patient, and administering one or more neuropharmaceutical agents to the neurologically paralyzed patient, wherein the electrical stimulation is below an amount that fully activates a spinal circuit such that the spinal circuit is at least partially activatable by the addition of supraspinal signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of enabling one or more bodily functions in a neurologically paralyzed patient, the method comprising:
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stimulating the spinal cord of the neurologically paralyzed patient using an electrode array while subjecting the neurologically paralyzed patient to physical training, and administering one or more neuropharmaceutical agents to the neurologically paralyzed patient, wherein at least one of the stimulating or physical training activates at least one spinal circuit by at least one of supraspinal information and proprioceptive information derived from the region of the neurologically paralyzed patient where the one or more bodily functions occur. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification