System and method for ultrasound ablation of tissue while compensating for collateral tissue

• US 9,907,983 B2
• Filed: 09/28/2012
• Issued: 03/06/2018
• Est. Priority Date: 10/30/2008
• Status: Active Grant

• Current Assignee: Auris Health, Inc. (Johnson & Johnson)
• Original Assignee: VytronUS, Inc. (Johnson & Johnson)
• Inventors: Thapliyal, Hira V., Gallup, David A., Arenson, James W.
• Primary Examiner(s): Akar, Serkan
• Application Number:
  US13/630,727
• Publication Number:
  US 20130096594A1
• Time in Patent Office: 1,985 Days
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/4893 Nerves
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 90/98 using electromagnetic means, e.g. transponders
• CPC Class Codes: A61N 2007/0026 Stimulation of nerve tissue
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

A tissue ablation method for treating atrial fibrillation in a patient comprises locating an ostium of a pulmonary vein and positioning an interventional catheter adjacent the ostium. The interventional catheter has an energy source. Collateral tissue adjacent the ostium is located and tissue around the ostium is ablated with energy from the energy source so as to form a contiguous lesion circumscribing the ostium. The lesion blocks aberrant electrical pathways in the tissue so as to reduce or eliminate the atrial fibrillation. The ablating is modified so as to avoid ablating or otherwise damaging the collateral tissue.

Claims

1. A method for ablating tissue, said method comprising:

providing a catheter comprising an ultrasound transducer adjacent a distal end thereof, the ultrasound transducer configured to provide ablation energy and sensing energy;

positioning the ultrasound transducer adjacent target tissue;

ablating the target tissue with the ablation energy, the target tissue being ablated by providing a beam of ultrasound with the ultrasound transducer while moving the catheter to move the beam of ultrasound along a lesion path, thereby forming a continuous lesion in the target tissue;

disposing a detection device adjacent collateral tissue, the collateral tissue adjacent the target tissue, and the collateral tissue being different from the target tissue;

providing a processor coupled to the detection device and the motor unit to cooperate with the catheter, where the processor is instructed to perform the steps of;

identifying a location of the collateral tissue with the detection device; and

modifying the lesion path along which the beam of ultrasound is moved according to the instructions from the processor based on the identified location of the collateral tissue thereby avoiding or minimizing ablation of the collateral tissue,

wherein modifying the lesion path comprises using a motor drive that is directed by the processor to move a tip of the catheter forwards or backwards, the motor drive being operatively coupled to the detection device and the catheter.

2. The method of claim 1, further comprising sensing one or more characteristics of the collateral tissue with a sensor separate from the ultrasound transducer.

3. The method of claim 1, wherein the positioning comprises positioning the catheter intravascularly.

4. The method of claim 1, further comprising identifying or characterizing properties of the collateral tissue.

5. The method of claim 1, wherein the identifying is performed before the ablating.

6. The method of claim 1, wherein the identifying is performed during the ablating.

7. The method of claim 1, wherein the method further comprises ablating the target tissue with the ablation energy while moving the beam of ultrasound along the modified lesion path.

8. The method of claim 1, wherein the modifying further comprises adjusting energy in the beam of ultrasound energy in order to avoid ablating the collateral tissue.

9. The method of claim 1, wherein the lesion comprises a transmural lesion.

10. The method of claim 1, wherein the lesion comprises a ring shape, an elliptical shape, a linear shape, a curvilinear shape, or a combination thereof.

11. The method of claim 1, wherein the beam of energy is a collimated beam of ultrasound energy.

12. The method of claim 1, wherein the identifying comprises emitting the sensing energy from the ultrasound transducer towards the detection device, and sensing with the ultrasound transducer energy reflected by the detection device to identify the location of the collateral tissue.

13. The method of claim 12, wherein emitting the sensing energy comprises emitting the sensing energy from the ultrasound transducer in amplitude mode, wherein the method further comprises determining a tissue thickness based on the reflected sensing energy, and wherein the identifying comprises identifying the location of the collateral tissue based on the tissue thickness.

14. The method of claim 1, wherein the ablating comprises ablating while moving the beam of ultrasound without contacting the target tissue with the ultrasound transducer and the distal end of the catheter.

15. A system for ablating tissue, said system comprising:

a catheter comprising an ultrasound transducer adjacent a distal end thereof, wherein the ultrasound transducer is configured to deliver ablation energy comprising a beam of ultrasound energy to target tissue and to move the beam of ultrasound energy along a lesion path, thereby ablating the target tissue and forming a continuous lesion in the target tissue, and

a device comprising an elongated shaft and a detection device disposed adjacent a distal portion of the elongated shaft, wherein the device is configured to position the detection device adjacent a collateral tissue different from the target tissue, and wherein the detection device is configured to allow identification of a location of the collateral tissue;

a motor unit operatively coupled to the device and the catheter; and

a processor operatively coupled to the detection device and the motor unit,

wherein the processor comprises instructions stored on non-transient, computer readable storage media to instruct the device to cooperate the catheter to modify the lesion path along which the beam of ultrasound energy is moved based on the identified location of the collateral tissue, and wherein the processor directs the motor unit to move the catheter along the modified lesion path;

thereby avoiding or minimizing ablation of the collateral tissue.

16. The system of claim 15, further comprising a sensor separate from the ultrasound transducer, the sensor configured to sense one or more characteristics of the collateral tissue.

17. The system of claim 15, wherein the beam of ultrasound energy is a collimated beam of ultrasound energy.

18. The system of claim 15, wherein the ultrasound transducer is further configured to emit sensing energy towards the detection device, and sense energy reflected by the detection device to identify the location of the collateral tissue.

19. The system of claim 18, wherein the ultrasound transducer is configured to emit the sensing energy in amplitude mode, wherein the system is configured to determine a tissue thickness based on the reflected sensing energy, and wherein the location of the collateral tissue is identified based on the tissue thickness.

20. The system of claim 15, wherein the ultrasound transducer and the distal end of the catheter do not contact the target tissue while the beam of ultrasound energy is moved along the lesion path.

21. A method for ablating tissue, said method comprising:

(a) providing a system that comprises;

(i) a catheter that comprises an ultrasound transducer adjacent a distal end thereof, wherein the ultrasound transducer is configured to deliver ablation energy that comprises a beam of ultrasound energy to target tissue and to move the beam of ultrasound energy along a lesion path, thereby ablating the target tissue and forming a continuous lesion in the target tissue;

(ii) a device that comprises an elongated shaft and a detection device disposed adjacent a distal portion of the elongated shaft, wherein the device is configured to position the detection device adjacent a collateral tissue different from the target tissue, and wherein the detection device is configured to allow identification of a location of the collateral tissue;

(iii) a motor unit operatively coupled to the device and the catheter; and

(iv) a processor operatively coupled to the detection device and the motor unit, wherein the processor comprises instructions stored on non-transient, computer readable storage media to instruct the device to cooperate the catheter to modify the lesion path along which the beam of ultrasound energy is moved based on the identified location of the collateral tissue, and wherein the processor directs the motor unit to move the catheter along the modified lesion path;

thereby avoiding or minimizing ablation of the collateral tissue;

(b) positioning the ultrasound transducer adjacent target tissue; and

(c) ablating the target tissue to form a continuous lesion in the target tissue to form a lesion path.

22. The method of claim 21, the processor is further instructed to identify a location of the collateral tissue.

23. The method of claim 22, further comprising modifying the lesion path based on the identifying of the location of the collateral tissue thereby avoiding or minimizing ablation of the collateral tissue;

wherein modifying the lesion path comprises using the motor unit to move the catheter forwards or backwards.

24. The method of claim 23, wherein the identifying is performed before the ablating.

25. The method of claim 23, wherein the identifying is performed during the ablating.

26. The method of claim 23, wherein the modifying further comprises adjusting energy in the beam of ultrasound energy in order to avoid ablating the collateral tissue.

27. The method of claim 22, further comprising sensing one or more characteristics of the collateral tissue with a sensor separate from the ultrasound transducer.

28. The method of claim 22, wherein the identifying comprises emitting sensing energy from the ultrasound transducer towards the detection device, and sensing with the ultrasound transducer energy reflected by the detection device to identify the location of the collateral tissue.

29. The method of claim 28, wherein emitting the sensing energy comprises emitting the sensing energy from the ultrasound transducer in amplitude mode, wherein the method further comprises determining a tissue thickness based on the reflected sensing energy, and wherein the identifying comprises identifying the location of the collateral tissue based on the tissue thickness.

30. The method of claim 21, wherein the positioning comprises positioning the catheter intravascularly.

31. The method of claim 21, wherein the lesion comprises a transmural lesion.

32. The method of claim 21, wherein the lesion comprises a ring shape, an elliptical shape, a linear shape, a curvilinear shape, or a combination thereof.

33. The method of claim 21, wherein the ablating comprises ablating while moving the beam of ultrasound without contacting the target tissue with the ultrasound transducer and the distal end of the catheter.