Accommodating lens with cavity

• US 9,910,296 B2
• Filed: 08/25/2017
• Issued: 03/06/2018
• Est. Priority Date: 11/11/2015
• Status: Active Grant

• Current Assignee: Onefocus Vision, Inc.
• Original Assignee: Onefocus Vision, Inc.
• Inventors: Harant, Adam, Davenport, Amelia, Cramer, Neil, Waite, Steve, Gupta, Amitava, Link, William J., Alhakimi, Gamil, Studnicki, Lisa, Alhakimi, Musa
• Primary Examiner(s): Won, Bumsuk
• Assistant Examiner(s): DUONG, HENRY ABRAHAM
• Application Number:
  US15/686,231
• Publication Number:
  US 20170371180A1
• Time in Patent Office: 193 Days
• Field of Search: 206 51, 264 17, 264 23, 264 26, 264241, 35115968, 35115904, 523106, 523107, 523916
• CPC Class Codes: B29C 39/021 by casting in several steps
• CPC Class Codes: B29C 39/10 incorporating preformed parts or layers, e.g. casting around inserts or for coating articles coating a surface by casting in general B05D1/30, B29C39/126 takes precedence
• CPC Class Codes: B29C 39/12 Making multilayered or multicoloured articles B29C39/021 takes precedence
• CPC Class Codes: B29C 41/22 Making multilayered or multicoloured articles
• CPC Class Codes: B29D 11/00 Producing optical elements, e.g. lenses or prisms grinding or polishing of optical elements B24B; constructional form of optical elements G02B; optical parts of spectacles G02C7/00
• CPC Class Codes: B29D 11/00038 Production of contact lenses
• CPC Class Codes: B29D 11/00048 composed of parts with dissimilar composition B29D11/00057 takes precedence
• CPC Class Codes: B29D 11/00125 Auxiliary operations, e.g. removing oxygen from the mould, conveying moulds from a storage to the production line in an inert atmosphere
• CPC Class Codes: B29D 11/00134 Curing of the contact lens material
• CPC Class Codes: B29K 2105/0002 monomers or prepolymers
• CPC Class Codes: B29K 2105/0035 Medical or pharmaceutical agents
• CPC Class Codes: B29K 2105/20 Inserts
• CPC Class Codes: B29K 2629/04 PVOH, i.e. polyvinyl alcohol B29K2631/04 takes precedence
• CPC Class Codes: B29K 2995/0059 Degradable
• CPC Class Codes: B29L 2011/0041 Contact lenses
• CPC Class Codes: C08L 101/14 the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: G02B 1/04 made of organic materials, e.g. plastics G02B1/08 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: G02C 7/04 : Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: G02C 7/048 : Means for stabilising the orientation of lenses in the eye
• CPC Class Codes: G02C 7/049 : Contact lenses having special fitting or structural features achieved by special materials or material structures
• CPC Class Codes: G02C 7/085 : Fluid-filled lenses, e.g. electro-wetting lenses

Abstract

A lens comprises an internal cavity structure formed by dissolution of a soluble insert material. The internal soluble material may dissolve through a body of a lens such as a contact lens in order to form the cavity within the contact lens. The cavity within the lens can be shaped in many ways, and corresponds to the shape of the dissolved material, such that many internal cavity shapes can be readily fabricated within the contact lens. The insert can be placed in a mold with a pre-polymer material, and the pre-polymer material cured with the insert placed in the mold to form the lens body. The polymerized polymer may comprise a low expansion polymer in order to inhibit expansion of the lens when hydrated. The polymer may comprise a hydrogel when hydrated. The soft contact lens material comprises a sufficient amount of cross-linking to provide structure to the lens and shape the cavity.

Claims

1. A soft contact lens for correcting vision of an eye, comprising:

a hydrogel contact lens body comprising water and a cross-linked polymer, wherein the contact lens body defines an internal cavity comprising a fluid and wherein the cross-linked polymer allows water to diffuse in and out of the contact lens body to the cavity from an external surface of the contact lens body, and wherein the cavity is shaped to correct vision when in equilibrium with tear fluid of the eye.

2. The soft contact lens of claim 1, wherein the contact lens body and the cavity are configured together to increase optical power by at least 2 D with an increase in internal pressure within a range from about 20 Pascals (Pa) to about 50 Pa and wherein the cavity comprises a volume containing the first fluid within a range from about 0.5 mm³ to about 5 mm³ and wherein the contact lens body comprises a modulus within a range from about 0.25 MPa to about 2 MPa and wherein a hydrogel material of the contact lens body comprises an equilibrium water content within a range from about 30% to about 70%.

3. The soft contact lens of claim 1, wherein the contact lens body comprises internal surfaces defining the cavity, the internal surfaces comprising internal surface structures defined with erosion of a material from within the cavity.

4. The soft contact lens of claim 1, wherein the contact lens body comprises a first portion on a first side of the cavity and a second portion of the second side of the cavity with the cavity extending therebetween, the first portion bonded to the second portion away from the cavity to contain fluid within the cavity and optionally wherein an interface of the first material bonded to the second material is detectable by dark field microscopy.

5. The soft contact lens of claim 1, wherein the cross-linked polymer directly contacts the fluid of the cavity.

6. The soft contact lens of claim 1, wherein the cross-linked polymer comprises sufficient stiffness to retain a shape of an insert dissolved from within the contact lens body to form the cavity.

7. The soft contact lens of claim 1, wherein the cavity comprises a dissolved material having a molecular weight within a range from about 3 to 7 k Daltons, and wherein the dissolved material is capable of diffusing through the cross-linked polymer of the contact lens body.

8. The soft contact lens of claim 7, wherein the dissolved material comprises a material of an insert dissolved to form the cavity.

9. The soft contact lens of claim 8, wherein the cavity comprises a shape profile corresponding to the dissolved insert.

10. The soft contact lens of claim 1, wherein the cavity comprises an optical portion configured to correct vision of the eye and a lower portion fluidically coupled to the optical portion, and wherein the optical portion is configured to provide near vision correction when an eyelid engages the lower portion.

11. The soft contact lens of claim 10, wherein the cross-linked polymer comprises a sufficient amount of cross-linking to retain fluid in the optical portion when the lower portion engages the eyelid to correct near vision of the eye.

12. The soft contact lens of claim 10, wherein the contact lens body comprises one or more hinges coupled to the optical portion and the lower portion.

13. The soft contact lens of claim 1, wherein the cavity comprises one or more internal structures shaped with an erodible material.

14. The soft contact lens of claim 1, wherein the cross-linked polymer comprises a hydrogel.

15. The soft contact lens of claim 1, wherein the cavity is comprises a first fluid, not hermetically sealed, wherein the contact lens body is permeable to a second fluid in which the contact lens body is packaged, and the cavity is in equilibrium with the second fluid in which the contact lens body is packaged.

16. The soft contact lens of claim 1, wherein the cross-linked polymer comprises a homogeneous polymer.

17. The soft contact lens of claim 1, wherein the cross-linked polymer comprises a homopolymer.

18. The soft contact lens of claim 1, wherein said polymer comprises hydrogel.

19. The soft contact lens of claim 1, wherein the cross-linked polymer comprises channels sized to permit diffusion of water between the cavity and outside the contact lens body and to inhibit bacteria from entering the cavity from outside the contact lens body.

20. The soft contact lens of claim 1, wherein the cross-linked polymer allows molecules having a radius of gyration of no more than 50 nm to diffuse through the cross-linked polymer of the contact lens body.

21. The soft contact lens of claim 20, wherein the cross-linked polymer allows molecules having a radius of gyration of no more than 15 nm to diffuse through the cross-linked polymer of the contact lens body.

22. The soft contact lens of claim 1, wherein the cavity comprises a dissolved material having a molecular weight within a range from about 3 to about 10 k Daltons, and wherein the dissolved material is capable of diffusing through the cross-linked polymer of the contact lens body.

23. The soft contact lens of claim 1, wherein the cavity comprises a volume within a range from about 1 to 5 uL.

24. The soft contact lens of claim 1, wherein the first fluid comprises a refractive index within a range from about 1.31 to about 1.37 and wherein the contact lens body comprises an index of refraction within a range from about 1.37 to about 1.48.

25. The soft contact lens of claim 1, wherein the contact lens body has an anterior side with an anterior thickness defined between an anterior surface of the contact lens body and an anterior surface of the internal cavity, and wherein the contact lens body has a posterior side with a posterior thickness defined between a posterior surface of the contact lens body and a posterior surface of the inner cavity.

26. The soft contact lens of claim 25, wherein the anterior thickness is less than the posterior thickness.

27. The soft contact lens of claim 25, wherein the anterior thickness is within a range defined between any two of the following values:

about 10 microns, about 25 microns, about 50 microns, about 100 microns, about 150 microns, and 200 microns.

28. The soft contact lens of claim 25, wherein the posterior thickness is within a range defined between any two of the following values:

about 10 microns, about 100 microns, and about 200 microns.

29. The soft contact lens of claim 25, wherein a thickness of the internal cavity from the anterior surface to the posterior surface thereof is within a range defined between any two of the following values:

about 0.5 microns, about 15 microns, about 50 microns, and about 100 microns.

30. The soft contact lens of claim 25, wherein a thickness of the contact lens body from the anterior surface to the posterior surface thereof is in a range from about 80 microns to about 250 microns.

31. The soft contact lens of claim 1, wherein a shape-changing portion of the lens used to correct vision has RMS optical path difference aberrations of about 0.4 microns or less in a far vision configuration when placed on an eye.

32. The soft contact lens of claim 1, wherein an inner surface of the cross-linked polymer defining the cavity comprises a shape profile corresponding to a solid material dissolved to form the cavity.

33. The soft contact lens of claim 32, wherein the inner surface of the cross-linked polymer defining the cavity comprises a structure corresponding to the solid material dissolved to form the cavity.

34. The soft contact lens of claim 32, wherein the inner surface of the cavity comprises an optically smooth surface over an inner portion of the cavity through which light passes to correct vision.

35. The soft contact lens of claim 34, wherein the optically smooth surface has a wavefront distortion of about 0.3 microns or less measured through the optically smooth surface.

36. The soft contact lens of claim 34, wherein the optically smooth surface comprises no visually perceptible artifacts when worn by a patient.

37. The soft contact lens of claim 34, wherein the optically smooth surface has an RMS value of about 0.2 microns or less.

38. The soft contact lens of claim 32, wherein the inner surface of the cavity comprises a residual surface structure from the solid material dissolved to form the cavity.

39. The soft contact lens of claim 32, wherein the inner surface of the cavity has an RMS value of about 50 nm or less.

40. The soft contact lens of claim 32, wherein the inner surface of the cavity has an RMS value in a range defined between any two of the following values:

about 5 nm, about 10 nm, about 15 nm, about 300 nm, about 500 nm, and about 1000 nm.

41. A soft contact lens for correcting vision of an eye, comprising:

a hydrogel contact lens body comprising water and a cross-linked polymer, wherein the contact lens body defines an internal cavity comprising a fluid and wherein the cross-linked polymer allows water to diffuse in and out of the contact lens body to the cavity from an external surface of the contact lens body, the contact lens body comprising an anterior surface and a posterior surface, the posterior surface and the anterior surface and the cavity shaped to correct vision with the cavity in equilibrium with tear fluid of the eye.