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Methods for genome assembly and haplotype phasing

  • US 9,910,955 B2
  • Filed: 05/27/2016
  • Issued: 03/06/2018
  • Est. Priority Date: 02/01/2013
  • Status: Active Grant
First Claim
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1. A method of genome assembly comprising:

  • obtaining naked DNA from a sample taken from a complex biological environment;

    obtaining a plurality of contigs corresponding to DNA from said sample;

    complexing said naked DNA with isolated nuclear proteins to form reconstituted chromatin;

    generating a plurality of read pairs from data produced by probing the physical layout of the reconstituted chromatin;

    mapping the plurality of read pairs to the plurality of contigs thereby producing read-mapping data; and

    arranging the contigs using the read-mapping data to assemble the contigs into genome assemblies, such that contigs having common read pairs are positioned in a common genome.

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