Method for preparing a polymeric reagent

• US 9,913,913 B2
• Filed: 06/16/2016
• Issued: 03/13/2018
• Est. Priority Date: 05/23/2003
• Status: Expired due to Term

• Current Assignee: Nektar Therapeutics
• Original Assignee: Nektar Therapeutics
• Inventors: Harris, J. Milton, Kozlowski, Antoni, McManus, Samuel P., Bentley, Michael D., Charles, Stephen A.
• Primary Examiner(s): Fubara, Blessing M
• Application Number:
  US15/184,182
• Publication Number:
  US 20160324974A1
• Time in Patent Office: 635 Days
• CPC Class Codes: A61K 31/357 having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• CPC Class Codes: A61K 31/4025 not condensed and containing further heterocyclic rings, e.g. cromakalim
• CPC Class Codes: A61K 31/52 Purines, e.g. adenine
• CPC Class Codes: A61K 38/095 Oxytocins; Vasopressins; Related peptides
• CPC Class Codes: A61K 38/1816 Erythropoietin [EPO]
• CPC Class Codes: A61K 38/193 Colony stimulating factors [CSF]
• CPC Class Codes: A61K 38/212 IFN-alpha
• CPC Class Codes: A61K 38/215 IFN-beta
• CPC Class Codes: A61K 38/24 Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
• CPC Class Codes: A61K 38/27 Growth hormone [GH], i.e. somatotropin
• CPC Class Codes: A61K 38/37 Factors VIII
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: C08G 65/329 with organic compounds
• CPC Class Codes: C08G 65/33337 cyclic
• CPC Class Codes: C08G 65/33344 containing carbamate group

Abstract

A method for preparing a polymeric reagent is provided, which method includes the optional step of forming an N-hydroxysuccinimdyl ester derivative. Related methods, preparations, and so forth are also provided.

Claims

1. A method comprising:

reacting

2. The method of claim 1, comprising the optional step of reacting

3. The method of claim 1, wherein the poly(ethylene glycol) has a molecular weight of from about 1,000 Daltons to about 60,000 Daltons.

4. The method of claim 1, wherein the poly(ethylene glycol) has a molecular weight of from about 2,000 Daltons to about 50,000 Daltons.

5. The method of claim 1, wherein the poly(ethylene glycol) has a molecular weight of from about 5,000 Daltons.

6. The method of claim 1, wherein the poly(ethylene glycol) has a molecular weight of from about 10,000 Daltons.

7. The method of claim 1, wherein the poly(ethylene glycol) has a molecular weight of from about 20,000 Daltons.