Systems and methods of suppressing unwanted ions

• US 9,916,971 B2
• Filed: 02/28/2017
• Issued: 03/13/2018
• Est. Priority Date: 02/26/2010
• Status: Active Grant

• Current Assignee: Perkin Elmer Life Sciences
• Original Assignee: PerkinElmer Health Sciences, Inc. (Revvity, Inc.)
• Inventors: Badiei, Hamid, Bazargan, Samad
• Primary Examiner(s): SOUW, BERNARD E
• Application Number:
  US15/444,792
• Publication Number:
  US 20170301528A1
• Time in Patent Office: 378 Days
• Field of Search: 250281-300, 250526
• CPC Class Codes: H01J 49/00 Particle spectrometers or separator tubes
• CPC Class Codes: H01J 49/0031 Step by step routines describing the use of the apparatus H01J49/0081 takes precedence
• CPC Class Codes: H01J 49/0045 characterised by the fragmentation or other specific reaction
• CPC Class Codes: H01J 49/005 by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
• CPC Class Codes: H01J 49/0072 by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation
• CPC Class Codes: H01J 49/0077 specific reactions other than fragmentation
• CPC Class Codes: H01J 49/061 Ion deflecting means, e.g. ion gates
• CPC Class Codes: H01J 49/10 Ion sources; Ion guns
• CPC Class Codes: H01J 49/105 using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
• CPC Class Codes: H01J 49/24 Vacuum systems, e.g. maintaining desired pressures

Abstract

Certain embodiments described herein are directed to systems including a cell downstream of a mass analyzer. In some instances, the cell is configured as a reaction cell, a collision cell or a reaction/collision cell. The system can be used to suppress unwanted ions and/or remove interfering ions from a stream comprising a plurality of ions.

Claims

1. A method comprising:

selecting native ions comprising a single mass-to-charge ratio from an ion beam comprising a plurality of ions with different mass-to-charge ratios; and

providing the selected, native ions to a downstream cell.

2. The method of claim 1, further comprising selecting the native ions using a mass analyzer.

3. The method of claim 1, further comprising configuring the cell to remove interfering ions in the native ions.

4. The method of claim 3, further comprising configuring the cell as a reaction cell.

5. The method of claim 3, further comprising configuring the cell as a collision cell.

6. The method of claim 3, further comprising configuring the cell to operate in both a collision mode and a reaction mode.

7. The method of claim 1, further comprising configuring the system with an additional cell upstream of the downstream cell.

8. The method of claim 1, further comprising configuring the system with an ion source, a mass analyzer and a detector, in which the ion source is upstream of the mass analyzer, the mass analyzer is upstream of the downstream cell and between the ion source and the downstream cell and in which the detector is downstream of the downstream cell.

9. The method of claim 1, further comprising reacting the selected, native ions with a reactant gas effective to react with interfering ions in the selected, native ions.

10. The method of claim 1, further comprising colliding the selected, native ions with a collision gas effective to alter interfering ions in the selected, native ions.

11. The method of claim 2, wherein the mass analyzer upstream of the downstream cell is the only mass analyzer used to select the native ions.