Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
First Claim
1. A method of reducing risk of a cardiovascular event in a subject on statin therapy (a) with residual atherogenic dyslipidemia and clinically evident cardiovascular disease or (b) without clinically evident cardiovascular disease but with increased risk of cardiovascular disease, the method comprising administering to the subject a pharmaceutical composition comprising about 4 g of ethyl icosapentate per day for a period of at least about 2 years, wherein said administration reduces risk of cardiovascular disease, need for coronary revascularization, risk of unstable angina, risk for stroke and/or risk for myocardial infarction.
3 Assignments
0 Petitions
Accused Products
Abstract
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
-
Citations
18 Claims
- 1. A method of reducing risk of a cardiovascular event in a subject on statin therapy (a) with residual atherogenic dyslipidemia and clinically evident cardiovascular disease or (b) without clinically evident cardiovascular disease but with increased risk of cardiovascular disease, the method comprising administering to the subject a pharmaceutical composition comprising about 4 g of ethyl icosapentate per day for a period of at least about 2 years, wherein said administration reduces risk of cardiovascular disease, need for coronary revascularization, risk of unstable angina, risk for stroke and/or risk for myocardial infarction.
Specification