Oncolytic vaccinia virus cancer therapy
First Claim
1. A method of inducing oncolysis in a human subject having a tumor comprising intratumorally administering to said subject one or more single doses of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a purified TK-deficient, replication-competent vaccinia virus vector wherein said single dose comprises at least 1×
- 109 pfu.
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Abstract
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations. Further aspects of the invention include methods for inducing oncolysis or collapse of tumor vasculature in a subject having a tumor comprising administering to a subject at least 1×108 infectious viral particles of a TK-deficient, GM-CSF-expressing, replication-competent vaccinia virus vector sufficient to induce oncolysis of cells in the tumor.
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20 Claims
- 1. A method of inducing oncolysis in a human subject having a tumor comprising intratumorally administering to said subject one or more single doses of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a purified TK-deficient, replication-competent vaccinia virus vector wherein said single dose comprises at least 1×
Specification