Systems and methods for reducing or preventing backflow in a delivery system
First Claim
1. A method of delivering a therapeutic agent to a patient, comprising:
- advancing a fluid conduit having a first outer sheath disposed therearound into tissue to compress tissue into a first tissue-receiving space defined between an exterior surface of the fluid conduit and an interior surface of a distal end of the first outer sheath and to urge a nose portion disposed at a location proximal to the first tissue-receiving space into contact with the tissue the nose portion tapering from a reduced distal diameter corresponding to an outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to an outside diameter of a catheter; and
delivering fluid containing the therapeutic agent under positive pressure through the catheter, through the fluid conduit, and into a portion of the tissue adjacent to a distal end of the fluid conduit.
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Accused Products
Abstract
Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.
196 Citations
10 Claims
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1. A method of delivering a therapeutic agent to a patient, comprising:
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advancing a fluid conduit having a first outer sheath disposed therearound into tissue to compress tissue into a first tissue-receiving space defined between an exterior surface of the fluid conduit and an interior surface of a distal end of the first outer sheath and to urge a nose portion disposed at a location proximal to the first tissue-receiving space into contact with the tissue the nose portion tapering from a reduced distal diameter corresponding to an outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to an outside diameter of a catheter; and delivering fluid containing the therapeutic agent under positive pressure through the catheter, through the fluid conduit, and into a portion of the tissue adjacent to a distal end of the fluid conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification