Current control for electrotransport drug delivery

• US 9,919,151 B2
• Filed: 03/05/2013
• Issued: 03/20/2018
• Est. Priority Date: 06/11/2012
• Status: Active Grant

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson), Incline Therapeutics, Inc. (Novartis Ag)
• Inventors: White, Bradley E., Hayter, Paul, Lemke, John, Satre, Scot, Chen, Corinna X., Read, Brian W., Dougherty, Jason E.
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): WILSON, LARRY ROSS
• Application Number:
  US14/406,969
• Publication Number:
  US 20150196754A1
• Time in Patent Office: 1,841 Days
• Field of Search: 604 20, 604 21, 604500, 604501, 607 62- 64, 323265, 323282-290
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).

Claims

1. An electrotransport drug delivery system having a power source that is controlled by feedback circuitry that is isolated from a patient terminal, the system comprising:

the power source;

the patient terminal comprising a first patient contact connected to the power source and a second patient contact connected to an isolation circuit; and

a sensing circuit configured to measure voltage, current or voltage and current at the isolation circuit, wherein the sensing circuit is configured to provide feedback controlling power at the first patient contact, wherein the second patient contact is connected to the sensing circuit only through the isolation circuit so that the second patient contact is electrically isolated from the sensing circuit.

2. The system of claim 1, wherein the isolation circuit comprises a transistor.

3. The system of claim 1, wherein the isolation circuit comprises a current control transistor controlled by an amplifier receiving input from a microcontroller.

4. The system of claim 1, wherein the sensing circuit is configured to compare the voltage, current or current and voltage at the isolation circuit to a threshold.

5. The system of claim 4 wherein the feedback circuit automatically controls the power source based on the comparison between the voltage, current or voltage and current at the isolation circuit and the threshold to regulate an applied current.

6. The system of claim 4 wherein the feedback circuit automatically controls the power source based on the comparison between the voltage, current or voltage and current at the isolation circuit and the threshold to regulate an applied current while minimizing power consumption.

7. The system of claim 1, wherein the sensing circuit provides input to a feedback circuit.

8. An electrotransport drug delivery system having a power source that is controlled by feedback circuitry that is isolated from a patient terminal, the system comprising:

the power source;

the patient terminal comprising a first patient contact connected to the power source and a second patient contact connected to an isolation circuit;

a feedback circuit configured to provide a control signal to the isolation circuit when the connection between the first patient contact and the second patient contact is closed; and

a sensing circuit configured to measure voltage, current or current and voltage at the isolation circuit when the connection is closed, wherein the sensing circuit is configured to provide feedback controlling power at the first patient contact;

wherein the second patient contact is connected to the feedback circuit and sensing circuit only though the isolation circuit.

9. The system of claim 8, wherein the isolation circuit comprises a transistor, and further wherein the second patient contact connected to a drain of the transistor and the control signal comprises a voltage applied to a gate of the transistor.

10. The system of claim 8, wherein the control signal provided to the isolation circuit is controlled by an amplifier receiving input from a microcontroller.

11. The system of claim 8, wherein the feedback circuit controls a voltage applied to the power source.

12. The system of claim 8, wherein the feedback circuit compares the voltage, current or current and voltage measured at the isolation circuit to a reference voltage or current.

13. The system of claim 12, wherein the feedback circuit controls the power source based on the comparison between the voltage measured at the isolation circuit and the reference voltage.

14. The system of claim 8, wherein the sensing circuit is isolated from the first and second patient contacts by the isolation circuit.

15. The system of claim 8, wherein the first patient contact is an anode and the second patient contact is a cathode.

16. The system of claim 8, wherein the power source is configured to deliver a constant current.

17. The system of claim 8, wherein the power source and feedback circuit are configured to deliver a constant current of about 170 μ

A.

18. The system of claim 8, wherein the connection between the first patient contact and the second patient contact is configured to be closed by a patient'"'"'s skin.

19. The circuit of claim 8, wherein the isolation circuit comprises a transistor located between the second patient contact and a sense resistor.

20. The system of claim 8, wherein the feedback circuit includes a digital to analogue converter for providing a constant current.