System and method for initiating a cell culture
First Claim
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1. A bioreactor system for culturing cells, comprising:
- a platform, wherein the platform comprises a platform heating element for generating first thermal energy on a surface area of the platform;
a first enclosure containing a thermal mass, wherein the first enclosure is positioned adjacent to the surface area, the thermal mass absorbing at least some of the first thermal energy from the platform;
a second enclosure containing a culture fluid and a gas mixture, wherein the first enclosure is positioned between the second enclosure and the platform, the thermal mass of the first enclosure is thermally coupled to the culture fluid; and
a cover positioned adjacent to the second enclosure, wherein the cover comprises a cover heating element for generating second thermal energy and the cover is thermally coupled to the second enclosure, wherein the second enclosure is positioned between the first enclosure and the cover.
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Abstract
System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
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Citations
20 Claims
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1. A bioreactor system for culturing cells, comprising:
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a platform, wherein the platform comprises a platform heating element for generating first thermal energy on a surface area of the platform; a first enclosure containing a thermal mass, wherein the first enclosure is positioned adjacent to the surface area, the thermal mass absorbing at least some of the first thermal energy from the platform; a second enclosure containing a culture fluid and a gas mixture, wherein the first enclosure is positioned between the second enclosure and the platform, the thermal mass of the first enclosure is thermally coupled to the culture fluid; and a cover positioned adjacent to the second enclosure, wherein the cover comprises a cover heating element for generating second thermal energy and the cover is thermally coupled to the second enclosure, wherein the second enclosure is positioned between the first enclosure and the cover. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of operating a bioreactor system for culturing cells, comprising:
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positioning a first enclosure on a surface area of a platform, wherein the first enclosure contains a thermal mass and the platform comprises a platform heating element; placing a second enclosure on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform, the second enclosure containing a culture fluid and a gas mixture; securing a cover on the second enclosure such that the cover is positioned adjacent to the second enclosure, wherein the cover comprises a cover heating element; generating first thermal energy on the surface area of the platform from the platform heating element and second thermal energy from the cover using the cover heating element, wherein a second temperature of the cover based from the second thermal energy is greater than a first temperature of the platform based from the first thermal energy; and culturing cells in the culture fluid of the second enclosure. - View Dependent Claims (16, 17, 18, 19)
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20. A bioreactor system for culturing cells, comprising:
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a platform pivotably mounted on a base such that opposing edges of the platform rotate about an axis of the base resulting in a rocking motion, wherein the platform comprises a platform heating element for generating first thermal energy on a surface area of the platform during the rocking motion; a first enclosure containing a thermal mass, wherein the first enclosure is positioned adjacent to the surface area of the platform, the thermal mass absorbing at least some of the first thermal energy generated from the platform; a second enclosure containing a culture fluid and a gas mixture, wherein the first enclosure is positioned between the second enclosure and the platform, the thermal mass thermally coupled to the culture fluid such that the culture fluid absorbs at least some of thermal energy from the first enclosure; and a cover positioned adjacent to the second enclosure and disposed on a top surface area of the second enclosure such that the cover is thermally coupled to the gas mixture, wherein the cover comprises a cover heating element for generating second thermal energy, at least some of the second thermal energy being absorbed by the second enclosure, and wherein the second enclosure is positioned between the first enclosure and the cover.
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Specification