System for quantifying blood flow in tissue and updating tissue baseline conditions
First Claim
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1. A method for determining perfusion in living tissue wherein physiological conditions and artifactual conditions are subject to change with time comprising the steps of:
- (1) establishing baseline criteria, comprising(A) determining an unperturbed temperature in a capillary bed;
(B) causing the unperturbed temperature in the capillary bed to change from the unperturbed temperature to a second temperature different from said unperturbed temperature for a time period, and(C) determining a value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value in the capillary bed during a first selected portion of said time period which is strongly affected by conductive factors;
(2) calculating, using a computing unit, a perfusion value for blood in the capillary bed at a second selected portion of said time period which is strongly affected by convective factors using said value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value;
(3) evaluating over time, using a computing unit, physiological and artifactual conditions to determine if baseline criteria established by step (1) are changed by a weighted combination of values of the evaluated physiological and artifactual conditions to fall outside a preset threshold indicative of perfusion measurement accuracy;
(4) establishing new baseline criteria by reinitiating step (1) when the baseline criteria established by step (1), as affected by the weighted combination of values of the evaluated physiological and artefactual conditions, fall outside the preset threshold; and
(5) determining if the baseline criteria in the capillary bed are stable, wherein if the baseline criteria in the capillary bed are not stable, then repeating step (1).
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Abstract
Methods and apparatus for determining blood flow in tissue are disclosed. The methods and apparatus are used to establish a baseline for both thermal properties of the tissue and non-physiologic conditions. Periodic changes in either or both constituents of the baseline are determined and, when the changes correspond to a need for a new baseline, a new baseline is established.
31 Citations
9 Claims
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1. A method for determining perfusion in living tissue wherein physiological conditions and artifactual conditions are subject to change with time comprising the steps of:
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(1) establishing baseline criteria, comprising (A) determining an unperturbed temperature in a capillary bed; (B) causing the unperturbed temperature in the capillary bed to change from the unperturbed temperature to a second temperature different from said unperturbed temperature for a time period, and (C) determining a value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value in the capillary bed during a first selected portion of said time period which is strongly affected by conductive factors; (2) calculating, using a computing unit, a perfusion value for blood in the capillary bed at a second selected portion of said time period which is strongly affected by convective factors using said value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value; (3) evaluating over time, using a computing unit, physiological and artifactual conditions to determine if baseline criteria established by step (1) are changed by a weighted combination of values of the evaluated physiological and artifactual conditions to fall outside a preset threshold indicative of perfusion measurement accuracy; (4) establishing new baseline criteria by reinitiating step (1) when the baseline criteria established by step (1), as affected by the weighted combination of values of the evaluated physiological and artefactual conditions, fall outside the preset threshold; and (5) determining if the baseline criteria in the capillary bed are stable, wherein if the baseline criteria in the capillary bed are not stable, then repeating step (1).
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2. A method for determining perfusion of blood in a volume of tissue wherein physiological conditions and artifactual conditions are subject to change with time comprising the steps of:
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(1) establishing thermal baseline criteria corresponding to thermal conditions of the volume of tissue comprising determining an unperturbed tissue temperature; (2) determining if the thermal baseline criteria in the volume of tissue are stable, wherein if thermal baseline criteria are not stable then repeating step 1; (3) causing the temperature of the volume of tissue to rise a predetermined amount from the unperturbed tissue temperature to a second temperature different from the unperturbed tissue temperature during a time interval; (4) calculating, using a computing unit, at least one of an intrinsic thermal conductivity value and a thermal diffusivity value for the volume of tissue during a first selected portion of said time interval which is strongly affected by conductive factors; (5) calculating, using a computing unit, perfusion in the volume of tissue at a second selected portion of said time interval which is strongly affected by convective factors using the value calculated during said first selected portion of said time interval; (6) determining if the thermal baseline criteria in the volume of tissue are stable, wherein if the thermal baseline criteria are not stable, then repeating step 1; (7) determining need for new baseline criteria for the volume of tissue comprising evaluating over time one or both of physiologic and artifact conditions to determine if baseline criteria established pursuant to step (1) are outside predetermined limits that indicate reliability of perfusion measurements; and (8) repeating step (1) when indicated by step (7). - View Dependent Claims (3, 4, 5)
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6. A method for determining perfusion in a volume of tissue wherein physiological conditions and artifactual conditions are subject to change with time comprising the steps of:
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(1) establishing baseline criteria, comprising (A) determining an unperturbed temperature of the tissue; (B) causing the temperature of the tissue to change from the unperturbed tissue temperature to a second temperature different from said unperturbed tissue temperature for a time period, and (C) determining a value or values for one or more thermal properties of tissue during a portion of said time period which is strongly affected by conductive factors; (2) calculating, using a computing unit, a perfusion value for the tissue during a portion of said time period which is strongly affected by convective factors using said thermal property value or values, (3) determining if the baseline criteria in the tissue are stable, wherein if the baseline criteria in the tissue are not stable, then repeating step (1); and (4) evaluating over time, using a computing unit, one or more physiological and artifactual conditions to determine if baseline criteria established by step (1) are changed by said one or more physiological and artifactual conditions to be outside predetermined limits that indicate reliability of perfusion measurements and if so repeating step (1). - View Dependent Claims (7, 8)
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9. A method for determining perfusion in living tissue wherein physiological conditions and artifactual conditions are subject to change with time comprising the steps of:
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(1) establishing baseline criteria, comprising (A) determining an unperturbed temperature in a capillary bed; (B) causing the unperturbed temperature in the capillary bed to change from the unperturbed temperature to a second temperature different from said unperturbed temperature for a time period, and (C) determining a value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value in the capillary bed during a first selected portion of said time period which is strongly affected by conductive factors; (2) calculating, using a computing unit, a perfusion value for blood in the capillary bed at a second selected portion of said time period which is strongly affected by convective factors using said value or values for at least one of an intrinsic thermal conductivity value and a thermal diffusivity value; (3) evaluating over time, using a computing unit, one or more physiological and artifactual conditions to determine if baseline criteria established by step (1) are changed by said one or more physiological and artifactual conditions to be outside predetermined limits that indicate reliability of perfusion measurements and if so repeating step (1); and (4) determining if the baseline criteria in the capillary bed are stable, wherein if the baseline criteria in the capillary bed are not stable, then repeating step (1).
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Specification