Systems and methods for regulation of one or more epidermal or dermoepidermal proteins
First Claim
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1. A method for modulating one or more cutaneous proteins, the method comprising the steps of:
- applying a mechanical strain to a portion of skin for a duration sufficient to affect upregulation of one or more epidermis-associated proteins or dermoepidermal-junction-associated proteins without substantially affecting upregulation of one or more or dermis-associated proteins in the portion of skin,wherein the step of applying the mechanical strain to a portion of skin includes applying a cyclical mechanical strain having a peak cyclic or oscillation frequency ranging from about 100 hertz to about 140 hertz for a duration sufficient to affect upregulation of one or more epidermis-associated proteins or dermoepidermal-junction-associated proteins without substantially affecting upregulation of one or more or dermis-associated proteins in the portion of skin; and
wherein the step of applying the mechanical strain to a portion of skin includes using an appliance, wherein the appliance includes;
a controller for selecting the peak cyclic or oscillation frequency;
a motor; and
a workpiece operably coupled to the motor, the workpiece including a plurality of contact points at which the workpiece is configured to contact the portion of skin;
wherein the plurality of contact points are located at a distance from each other that is based on an inverse of the selected peak cyclic or oscillation frequency;
wherein the motor is configured to move the workpiece, and wherein the appliance is configured such that, when the motor is moving the workpiece, the appliance has a resonant frequency based on the selected peak cyclic or oscillation frequency;
wherein, when the motor is operating and a force is applied to the appliance to bias the workpiece against the portion of skin, the workpiece produces a cyclical stimulus within the portion of skin at the selected peak cyclic or oscillation frequency.
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Abstract
The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.
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Citations
9 Claims
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1. A method for modulating one or more cutaneous proteins, the method comprising the steps of:
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applying a mechanical strain to a portion of skin for a duration sufficient to affect upregulation of one or more epidermis-associated proteins or dermoepidermal-junction-associated proteins without substantially affecting upregulation of one or more or dermis-associated proteins in the portion of skin, wherein the step of applying the mechanical strain to a portion of skin includes applying a cyclical mechanical strain having a peak cyclic or oscillation frequency ranging from about 100 hertz to about 140 hertz for a duration sufficient to affect upregulation of one or more epidermis-associated proteins or dermoepidermal-junction-associated proteins without substantially affecting upregulation of one or more or dermis-associated proteins in the portion of skin; and wherein the step of applying the mechanical strain to a portion of skin includes using an appliance, wherein the appliance includes;
a controller for selecting the peak cyclic or oscillation frequency;
a motor; anda workpiece operably coupled to the motor, the workpiece including a plurality of contact points at which the workpiece is configured to contact the portion of skin; wherein the plurality of contact points are located at a distance from each other that is based on an inverse of the selected peak cyclic or oscillation frequency; wherein the motor is configured to move the workpiece, and wherein the appliance is configured such that, when the motor is moving the workpiece, the appliance has a resonant frequency based on the selected peak cyclic or oscillation frequency; wherein, when the motor is operating and a force is applied to the appliance to bias the workpiece against the portion of skin, the workpiece produces a cyclical stimulus within the portion of skin at the selected peak cyclic or oscillation frequency. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification