Methods of adipolysis and compositions useful therein

• US 9,925,170 B2
• Filed: 09/30/2016
• Issued: 03/27/2018
• Est. Priority Date: 10/01/2015
• Status: Active Grant

• Current Assignee: Allergan Sales LLC (Abbvie Incorporated)
• Original Assignee: Kythera Biopharmaceuticals, Inc. (Abbvie Incorporated)
• Inventors: Lichtsteiner, Serge, Vasserot, Alain, Poloso, Neil
• Primary Examiner(s): VALENROD, YEVGENY
• Application Number:
  US15/283,246
• Publication Number:
  US 20170095447A1
• Time in Patent Office: 543 Days
• Field of Search: 514419
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/366 having six-membered rings, e.g. delta-lactones
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 3/06 Antihyperlipidemics

Abstract

Provided herein are pharmacologically active compositions suitable for topical application or injection directly for fat treatment without the need for surgical intervention.

Claims

1. A method of reducing subcutaneous fat in a subject in need thereof, the method comprising administering to the subject (i) a topical composition comprising a statin administered to the skin.

2. The method of claim 1, wherein the statin is selected from the group consisting of lovastatin, simvastatin, and fluvastatin.

3. The method of claim 1, wherein the statin is lovastatin.

4. The method of claim 1, wherein the statin is simvastatin.

5. The method of claim 1, wherein the statin is fluvastatin.

6. The method of claim 1, wherein the method excludes surgical intervention.

7. The method of claim 1, wherein the topical composition further comprises one or more additional active compounds.

8. The method of claim 7, wherein the one or more additional active compounds are selected from anti-inflammatory agents, analgesics, and dispersion agents.

9. The method of claim 1, wherein the topical composition further comprises one or more pharmaceutically acceptable and/or cosmetically acceptable excipients.

10. The method of claim 1, wherein the subcutaneous fat is located on the abdomen, chest, back, breast, buttocks, hips, thighs, legs, knees, arms, chin, neck, or face.

11. The method of claim 1, wherein the subject suffers from obesity, excess fat on the breast, gynecomastia, drug-induced obesity, hypothyroidism, pseudohypoparathyroidism, hypothalamic obesity, polycystic ovarian disease, depression, binge eating, postpartum obesity, obesity associated with smoking cessation, Prader-Willi syndrome, Bardet-Biedl syndrome, Cohen syndrome, Down syndrome, Turner syndrome, growth hormone deficiency, growth hormone resistance, leptin deficiency or resistance, Cushing syndrome, pseudo-Cushing syndrome, hypertrophy of dorsocervical fat/dorsocervical fat hypertrophy (“

buffalo hump”

), moon facies, lipoma, or excess fat on the chin.