Compositions comprising S-adenosylmethionine and a gallic acid ester
First Claim
1. A method of treating a disease or disorder comprising orally administering an oral composition comprising exogenous S-adenosylmethionine and at least one gallic acid ester to a patient in need thereof, wherein the disease or disorder is depression, Alzheimer'"'"'s disease, osteoarthritis, or a liver disease, and wherein the at least one gallic acid ester is selected from the group consisting of ethyl gallate, propyl gallate, isopropyl gallate, butyl gallate, isobutyl gallate, amyl gallate, isoamyl gallate, hexyl gallate, isohexyl gallate, heptyl gallate, isoheptyl gallate, octyl gallate, and isooctyl gallate.
3 Assignments
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Accused Products
Abstract
Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.
22 Citations
7 Claims
- 1. A method of treating a disease or disorder comprising orally administering an oral composition comprising exogenous S-adenosylmethionine and at least one gallic acid ester to a patient in need thereof, wherein the disease or disorder is depression, Alzheimer'"'"'s disease, osteoarthritis, or a liver disease, and wherein the at least one gallic acid ester is selected from the group consisting of ethyl gallate, propyl gallate, isopropyl gallate, butyl gallate, isobutyl gallate, amyl gallate, isoamyl gallate, hexyl gallate, isohexyl gallate, heptyl gallate, isoheptyl gallate, octyl gallate, and isooctyl gallate.
Specification