Biocompatible and bioabsorbable derivatized chitosan compositions
First Claim
1. A biocompatible, bioabsorbable deacetylated and reacetylated chitosan composition comprising a reacetylated chitosan having a molecular weight of about 90 kDa to about 170 kDa and a degree of N-deacetylation of between about 15% and 40%.
0 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
-
Citations
20 Claims
- 1. A biocompatible, bioabsorbable deacetylated and reacetylated chitosan composition comprising a reacetylated chitosan having a molecular weight of about 90 kDa to about 170 kDa and a degree of N-deacetylation of between about 15% and 40%.
-
9. A method of making a biocompatible, bioabsorbable chitosan composition comprising:
-
obtaining deacetylated chitosan; producing reacetylated chitosan from the deacetylated chitosan having a degree of N-deacetylation of between 15% and 30%; and resolubilizing the reacetylated chitosan to aqueous solution using carbonic acid. - View Dependent Claims (10, 11, 12, 13, 14, 15)
-
- 18. A biocompatible, bioabsorbable deacetylated and reacetylated chitosan composition comprising a reacetylated chitosan having a degree of N-deacetylation of between 15% and 30% and cross-linked with at least one of gelatin and collagen.
Specification