Devices and methods to use power spectrum or signal association for pain management

• US 9,925,378 B2
• Filed: 09/22/2015
• Issued: 03/27/2018
• Est. Priority Date: 09/22/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A., Bokil, Hemant
• Primary Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US14/861,524
• Publication Number:
  US 20160082255A1
• Time in Patent Office: 917 Days
• Field of Search: 607 45, 607 46
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined.

Claims

1. A non-transitory computer-readable medium having processor-executable instructions for adjusting stimulation parameters of an electrical stimulation system including a control module implanted in a patient, the processor-executable instructions when installed onto a device enable the device to perform actions, the actions comprising:

obtaining a biosignal of the patient;

analyzing the biosignal to determine whether the biosignal is indicative of pain; and

altering, by the device, at least one of the stimulation parameters of the electrical stimulation system in response to the biosignal when the biosignal is indicative of pain.

2. The non-transitory computer-readable medium of claim 1, wherein the actions further comprise delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the stimulation parameters including the at least one altered stimulation parameter.

3. The non-transitory computer-readable medium of claim 1, wherein the actions further comprise communicating the at least one altered stimulation parameter to an implantable control module.

4. The non-transitory computer-readable medium of claim 1, wherein the actions further comprise determining a power spectrum from the biosignal,

wherein altering at least one of the stimulation parameters comprises altering at least one of the stimulation parameters of the electrical stimulation system in response to the power spectrum.

6. The non-transitory computer-readable medium of claim 1, wherein the biosignal comprises at least one band of an electroencephalograph of the patient.

7. The non-transitory computer-readable medium of claim 6, wherein the at least one band is a theta band.

8. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising an antenna and a processor coupled to the antenna, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue; and

an external programming unit configured and arranged to communicate with the processor of the implantable control module using the antenna and to adjust stimulation parameters for production of the electrical stimulation signals, wherein the external programming unit comprises the non-transitory computer-readable medium of claim 1.

9. The electrical stimulation system of claim 8, further comprising at least one sensor configured and arranged to obtain the biosignal of the patient.

10. The electrical stimulation system of claim 8, wherein the actions further comprise determining a power spectrum from the biosignal,

wherein altering at least one of the stimulation parameters comprises altering at least one of the stimulation parameters of the electrical stimulation system in response to the power spectrum.

11. The electrical stimulation system of claim 8, further comprising the electrical stimulation lead coupleable to the implantable control module and comprising a plurality of electrodes disposed along a distal end portion of the electrical stimulation lead.

12. The electrical stimulation system of claim 8, wherein the biosignal comprises at least one band of an electroencephalograph of the patient, wherein the at least one band is a theta band.

5. A non-transitory computer-readable medium having processor-executable instructions for adjusting stimulation parameters of an electrical stimulation system including a control module implanted in a patient, the processor-executable instructions when installed onto a device enable the device to perform actions, the actions comprising:

obtaining at least two different biosignals of the patient,

determining a coherence or correlation between the at least two different biosignals, and

altering at least one of the stimulation parameters of the electrical stimulation system in response to the coherence or correlation between the at least two different biosignals.

19. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising an antenna and a processor coupled to the antenna, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue; and

an external programming unit configured and arranged to communicate with the processor of the implantable control module using the antenna and to adjust stimulation parameters for production of the electrical stimulation signals, wherein the external programming unit comprises the non-transitory computer readable medium of claim 5.

20. The non-transitory computer-readable medium of claim 5, wherein the two different biosignals are two different types of biosignals.

13. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue, wherein the implantable control module comprises

an antenna configured and arranged to receive input, and

a processor in communication with the antenna and configured and arranged to perform the following actions;

obtaining a biosignal of the patient;

analyzing the biosignal to determine whether the biosignal is indicative of pain;

altering, by the implantable control modules, at least one of the stimulation parameters of the electrical stimulation system in response to the biosignal when the biosignal is indicative of pain; and

delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using that at least one altered stimulation parameter.

14. The electrical stimulation system of claim 13, further comprising at least one sensor configured and arranged to obtain the biosignal of the patient.

15. The electrical stimulation system of claim 13, wherein the actions further comprise determining a power spectrum from the biosignal,

wherein altering at least one of the stimulation parameters comprises altering at least one of the stimulation parameters of the electrical stimulation system in response to the power spectrum.

16. The electrical stimulation system of claim 13, wherein the biosignal comprises at least two different biosignals,

wherein the actions further comprise determining a coherence, correlation, or association between the at least two different biosignals,

wherein altering at least one of the stimulation parameters comprises altering at least one of the stimulation parameters of the electrical stimulation system in response to the coherence, correlation, or association between the at least two different biosignals.

17. The electrical stimulation system of claim 13, wherein the biosignal comprises at least one band of an electroencephalograph of the patient, wherein the at least one band is a theta band.

18. The electrical stimulation system of claim 13, further comprising the electrical stimulation lead coupleable to the implantable control module and comprising a plurality of electrodes disposed along a distal end portion of the electrical stimulation lead.