Enhanced dorsal horn stimulation using multiple electrical fields

• US 9,925,380 B2
• Filed: 05/26/2017
• Issued: 03/27/2018
• Est. Priority Date: 07/24/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A., Hershey, Bradley Lawrence, Zhu, Changfang
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/606,235
• Publication Number:
  US 20170259062A1
• Time in Patent Office: 305 Days
• Field of Search: 607456
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/36192 Amplitude modulation

Abstract

A method of providing therapy to a patient having a medical condition comprises delivering electrical stimulation energy to the spinal cord of the patient in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord. The delivered electrical stimulation energy generates a plurality of electrical fields having different orientations that stimulate the dorsal horn neuronal elements.

Claims

1. A non-transitory machine-readable medium including instructions, which when executed by a neuromodulator connected to implanted electrodes which are operably positioned near a spinal cord for use by the neuromodulator to deliver a therapy to the spinal cord, cause the neuromodulator to provide the therapy using implanted electrodes to a patient having a medical condition, including deliver electrical stimulation energy as a pulsed electrical waveform to the spinal cord in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord, wherein the instructions, which when executed by the neuromodulator, cause the neuromodulator to generate a first electrical field having a first during at least a first pulse in the pulsed electrical waveform, generate a second electrical field having a second orientation during at least a second pulse in the pulsed electrical waveform, and generate a third electrical field having a third during at least a third pulse in the pulsed electrical waveform the first, second and third orientations being different from each other.

2. The non-transitory machine-readable medium of claim 1, further comprising instructions, which when executed by the neuromodulator, cause the neuromodulator to generate the electrical stimulation energy in repeating electrical field cycles, wherein each of the repeating electrical field cycles includes the first electrical field, the second electrical field, and the third electrical field.

3. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated a same number of pulses in each electrical field cycle.

4. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated a different number of pulses in each electrical field cycle.

5. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated in a same order during the electrical field cycles.

6. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated in a different order during the electrical field cycles.

7. The non-transitory machine-readable medium of claim 2, wherein the repeating electrical field cycles are bursted on and off at a burst frequency.

8. The non-transitory machine-readable medium of claim 2, wherein the electrical field cycles include a bias toward one of the first, second and third electrical fields relative to the other ones of the first, second and third electrical fields.

9. The non-transitory machine-readable medium of claim 1, wherein the first, second and third electrical fields are rotated through under a timing scheme.

10. The non-transitory machine-readable medium of claim 1, wherein the instructions, which when executed by the neuromodulator, cause the neuromodulator to deliver the electrical stimulation energy as the pulsed electrical waveform to the spinal cord include instructions, which when executed by the machine, cause the machine to provide an electrical field with a longitudinal voltage gradient along the spinal cord that is smaller than a voltage gradient in a transverse direction.

11. The non-transitory machine-readable medium of claim 10, wherein the first, second and third orientations are different medio-lateral directions.

12. The non-transitory machine-readable medium of claim 1, wherein the first electrical field is generated using a first current fractionalization, the second electrical field is generated using a second current fractionalization, and the third electrical field is generated using a third current fractionalization.

13. A system for providing a therapy to a patient using electrodes which are implanted operably near a spinal cord to deliver the therapy to the spinal cord, the system comprising a neuromodulator including stimulation output circuitry and a controller/processor:

the stimulation output circuitry being configured to be electrically connected to the electrodes; and

the controller/processor being configured to cooperate with the stimulation output circuitry to provide the therapy to the patient using the electrodes in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord including deliver electrical stimulation energy as a pulsed electrical waveform to the spinal cord, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to generate a first electrical field having a first during at least a first pulse in the pulsed electrical waveform, a second electrical field having a second during at least a second pulse in the pulsed electrical waveform, and a third electrical field having a third during at least a third pulse in the pulsed electrical waveform, the first, second and third orientations being different from each other.

14. The system of claim 13, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to deliver the electrical stimulation energy in repeating electrical field cycles, wherein each of the repeating electrical field cycles includes the first electrical field, the second electrical field, and the third electrical field.

15. The system of claim 14, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to burst the repeating electrical field cycles on and off at a burst frequency.

16. The system of claim 14, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to bias one of the first, second and third electrical fields relative to the other ones of the first, second and third electrical fields.

17. The system of claim 13, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to use a timing scheme to rotate through the first, second and third electrical fields.

18. The system of claim 13, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to provide an electrical field with a longitudinal voltage gradient along the spinal cord that is smaller than a voltage gradient in a transverse direction.

19. The system of claim 18, wherein the first, second and third orientations are different medio-lateral directions.

20. The system of claim 13, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to generate the first electrical field using a first current fractionalization, the second electrical field using a second current fractionalization, and the third electrical field using a third current fractionalization.