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Drug elution for in vivo protection of bio-sensing analytes

  • US 9,931,068 B2
  • Filed: 08/21/2014
  • Issued: 04/03/2018
  • Est. Priority Date: 08/21/2013
  • Status: Active Grant
First Claim
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1. A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:

  • a sensor housing;

    a light source within the sensor housing configured to emit excitation light;

    an analyte indicator covering a portion of the sensor housing, wherein the analyte indicator comprises one or more indicator molecules that reversibly bind the analyte, are positioned to be irradiated by the excitation light, and are configured to emit light indicative of the amount of the analyte in the medium within the living animal;

    a photodetector within the sensor housing, wherein the photodetector is sensitive to light emitted by the one or more indicator molecules and configured to generate a signal indicative of the amount of the analyte in the medium within the living animal;

    at least one drug eluting polymer matrix that covers a portion of the sensor housing and is separate and distinct from the analyte indicator, wherein the drug eluting polymer matrix (a) has a preformed shape and is applied to the sensor housing attaching the preformed shape to the sensor housing or (b) is applied to the sensor housing via dip coating or spray coating; and

    one or more therapeutic agents that reduce deterioration of the analyte indicator, are dispersed within the drug eluting polymer matrix, and include an anti-inflammatory drug.

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