Methods and devices for the treatment of ocular diseases in human subjects
First Claim
1. A method of treating macular edema in a human subject in need thereof, the method comprising,non-surgically administering an effective amount of a drug formulation comprising an anti-inflammatory drug to the suprachoroidal space (SCS) of the eye of the human subject in need of treatment of the macular edema;
- andfurther comprising non-surgically administering a second drug to the eye of the subject, wherein the second drug comprises a vascular endothelial growth factor (VEGF) antagonist.
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Accused Products
Abstract
Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
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Citations
12 Claims
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1. A method of treating macular edema in a human subject in need thereof, the method comprising,
non-surgically administering an effective amount of a drug formulation comprising an anti-inflammatory drug to the suprachoroidal space (SCS) of the eye of the human subject in need of treatment of the macular edema; - and
further comprising non-surgically administering a second drug to the eye of the subject, wherein the second drug comprises a vascular endothelial growth factor (VEGF) antagonist. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification