Treatment solution delivery in an extracorporeal blood treatment apparatus

• US 9,931,452 B2
• Filed: 03/20/2013
• Issued: 04/03/2018
• Est. Priority Date: 03/21/2012
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Pouchoulin, Dominique
• Primary Examiner(s): Felton, Michael J
• Assistant Examiner(s): WILL, KATHERINE A
• Application Number:
  US14/386,062
• Publication Number:
  US 20150034538A1
• Time in Patent Office: 1,840 Days
• Field of Search: None
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1643 with weighing of fresh and used dialysis fluid
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: A61M 2205/3396 Reservoirs being alternately filled and emptied for measuring flow rate or delivered volume
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

Blood treatment apparatus and methods of using the same are described herein that include two or more intermediate containers located between a treatment solution source and a port through which the treatment solution is to be delivered with the blood treatment apparatus. The weight of the intermediate containers is measured and used to control the refilling and emptying of treatment solution in the intermediate containers.

Claims

1. A blood treatment apparatus comprising:

a blood circuit that includes an arterial line intended to draw blood from a patient and a venous line intended to return blood to the patient;

a filter having a primary chamber and a secondary chamber separated by a semi-permeable membrane, wherein the blood circuit is configured to pass blood through the primary chamber, and wherein the blood treatment apparatus comprises a drain line exiting the secondary chamber to remove spent dialysate from the secondary chamber, and

a treatment solution delivery system having a treatment solution port and configured to deliver treatment solution to the secondary chamber and/or to the blood circuit through the treatment solution port, wherein the treatment solution delivery system comprises;

a first intermediate container;

a first gravimetric scale configured to weigh the first intermediate container;

a second intermediate container;

a second gravimetric scale configured to weigh the second intermediate container;

a source flow controller configured to deliver treatment solution from a treatment solution source to the first intermediate container weighed by the first gravimetric scale and to the second intermediate container weighed by the second gravimetric scale;

a sterilizing filter located between the treatment solution source and the treatment solution port such that treatment solution delivered to the treatment solution port from the treatment solution source passes through the sterilizing filter, wherein the sterilizing filter is located downstream from the source flow controller;

an output controller configured to control the flow of treatment solution from the first intermediate container and the second intermediate container to the treatment solution port;

a container selection controller located in a treatment solution path between the source flow controller and the output controller;

a control unit operably attached to the first gravimetric scale, the second gravimetric scale, the source flow controller, the container selection controller, and the output controller, wherein the control unit is configured to;

receive weight signals from the first and second gravimetric scales;

control the source flow controller, the container selection controller, and the output controller in a first mode in which treatment solution is delivered to the output controller while treatment solution leaves the first intermediate container and the second intermediate container fills with treatment solution, wherein treatment solution can flow into the second intermediate container from the source flow controller while treatment solution is prevented from flowing into the first intermediate container and treatment solution can flow from the first intermediate container to the output controller while treatment solution is prevented from flowing out of the second intermediate container;

control the source flow controller, the container selection controller, and the output controller in a second mode in which the second intermediate container delivers treatment solution to the output controller while the first intermediate container fills with treatment solution from the treatment solution source, wherein treatment solution can flow into the first intermediate container from the source flow controller while treatment solution is prevented from flowing into the second intermediate container and treatment solution can flow from the second intermediate container to the output controller while treatment solution is prevented from flowing out of the first intermediate container.

2. An apparatus according to claim 1, including a user interface to receive a set value for a dialysis fluid flow rate, the output controller is configured to deliver treatment solution through the treatment solution port at the dialysis fluid flow rate, the control unit being configured to:

receive the set value for the dialysis fluid flow rate;

control the output controller to cause the treatment solution to flow at the dialysis fluid flow rate in correspondence of the treatment solution port.

3. An apparatus according to claim 2, wherein the control unit is configured to control the output controller to cause the treatment solution to flow at the dialysis fluid flow rate based on the weight signals from the first and second gravimetric scales.

4. An apparatus according to claim 2, wherein the control unit is configured to control the output controller to cause the treatment solution to flow at the dialysis fluid flow rate in the first mode based on the weight signal from the first gravimetric scale.

5. An apparatus according to claim 2, wherein in the first mode the control unit is configured to control the output controller without using the weight signal from the second gravimetric scale.

6. An apparatus according to claim 2, wherein the control unit is configured to control the output controller to cause the treatment solution to flow at the dialysis fluid flow rate in the second mode based on the weight signal from the second gravimetric scale.

7. An apparatus according to claim 2, wherein in the second mode the control unit is configured to control the output controller without using the weight signal from the first gravimetric scale.

8. An apparatus according to claim 1, wherein the control unit is configured to switch a plurality of times between the first and the second mode during a treatment session.

9. An apparatus according to claim 1, wherein the control unit is configured to control the source flow controller to provide a fluid flow rate higher or at most equal to a dialysis fluid flow rate provided by the output controller.

10. An apparatus according to claim 1, wherein the control unit is configured to control the source flow controller, the container selection controller, and the output controller such that a continuous flow of treatment solution is provided to the treatment solution port when switching between the first mode and the second mode.

11. An apparatus according to claim 1, wherein the secondary chamber includes an inlet line to receive treatment fluid, the treatment solution port being configured to deliver treatment solution to the inlet line of the secondary chamber and/or to deliver treatment solution to the blood circuit.

12. An apparatus according to claim 1, wherein the first and second intermediate containers and the container selection controller are placed upstream the filter with respect to a treatment fluid flow direction.

13. An apparatus according to claim 1, wherein the apparatus further comprises a treatment solution source in fluid communication with the first and second intermediate containers to deliver treatment fluid to either the first or the second intermediate containers.

14. An apparatus according to claim 1, wherein the apparatus further comprises a sterilizing filter located between the source flow controller and the first and/or second intermediate container.

15. An apparatus according to claim 1, wherein the source flow controller is located between the treatment solution source and the first and second intermediate containers such that treatment solution delivered to the first intermediate container and the second intermediate container from the treatment solution source passes through the source flow controller.

16. An apparatus according to claim 1, wherein the container selection controller comprises a valve configured to have an open state in which flow through a line on which the valve acts is allowed and a closed state in which flow through a line on which the valve acts is prevented.

17. An apparatus according to claim 1, wherein the container selection controller comprises a pump configured to deliver treatment solution through a line on which the pump is located when the pump is operating and to prevent flow of treatment solution through the line on which the pump is located when the pump is not operating.

18. An apparatus according to claim 1, wherein the container selection controller comprises a multi-port valve, wherein in a first configuration the multi-port valve allows treatment solution from the treatment solution source to flow into the first intermediate container and prevent the treatment solution from flowing into the second intermediate container, and wherein in a second configuration the multi-port valve allows treatment solution from the treatment solution source to flow into the second intermediate container and prevent the treatment solution from flowing into the first intermediate container.

19. An apparatus according to claim 1, further comprising a first intermediate container outlet flow controller and a second intermediate container outlet flow controller, wherein the first intermediate container outlet flow controller and the second intermediate container outlet flow controller comprise a multi-port valve, wherein in a first configuration the multi-port valve allows treatment solution from the first intermediate container to flow to the output controller and prevent flow of treatment solution from the second intermediate container to the output controller, and wherein in a second configuration the multi-port valve allows treatment solution from the second intermediate container to flow to the output controller and prevent flow of treatment solution from the first intermediate container to the output controller.

20. An apparatus according to claim 1, wherein the control unit is configured to calculate, from the received weight signals, the amount of treatment solution delivered to the output controller from both the first intermediate container and the second intermediate container.

21. An apparatus according to claim 1, wherein the apparatus further comprises an air detector located between the treatment solution source and the treatment solution port such that treatment solution delivered to the treatment solution port from the treatment solution source passes through the air detector.

22. An apparatus according to claim 1, wherein the apparatus further comprises an air detector located between the treatment solution source and the source flow controller.

23. An apparatus according to claim 1, wherein in the first mode the control unit is configured to control the source flow controller to cause charge of the second intermediate container with the treatment solution based on the weight signal from the second gravimetric scale and without using the weight signal from the first gravimetric scale.

24. An apparatus according to claim 1, wherein in the second mode the control unit is configured to control the source flow controller to cause charge of the first intermediate container with the treatment solution based on the weight signal from the first gravimetric scale and without using the weight signal from the second gravimetric scale.

25. An apparatus according to claim 1, wherein the sterilizing filter comprises a vent configured to remove air entrained within the treatment solution, the vent comprising a hydrophobic membrane.