Protein activity modification
First Claim
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1. A method of modifying cardiac tissue behavior of a patient'"'"'s heart, comprising:
- applying a therapeutically effective electric field to at least a portion of said heart, said field when applied to the heart having an effect of modifying protein activation levels of at least one protein, thereby modifying a protein activation level of at least one protein; and
repeatedly applying said field at time intervals defining delays between successive applications, during which said delays said modified protein activation level decays, and said applying timed to increase said protein activation level of said at least one protein (i) beyond an amount achieved by a natural and/or paced excitation of said heart absent said applying and (ii) by an amount at least as high as a decay of said protein activation level between applications of said field,wherein said applying comprises modifying a protein activation level of protein already synthesized before said applying.
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Abstract
A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.
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Citations
43 Claims
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1. A method of modifying cardiac tissue behavior of a patient'"'"'s heart, comprising:
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applying a therapeutically effective electric field to at least a portion of said heart, said field when applied to the heart having an effect of modifying protein activation levels of at least one protein, thereby modifying a protein activation level of at least one protein; and repeatedly applying said field at time intervals defining delays between successive applications, during which said delays said modified protein activation level decays, and said applying timed to increase said protein activation level of said at least one protein (i) beyond an amount achieved by a natural and/or paced excitation of said heart absent said applying and (ii) by an amount at least as high as a decay of said protein activation level between applications of said field, wherein said applying comprises modifying a protein activation level of protein already synthesized before said applying. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. An apparatus for modifying cardiac tissue behavior of a patient'"'"'s heart, comprising:
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at least one electrode adapted to apply an electric field to at least a portion of said heart, said field when applied to the heart having an effect of modifying protein activation levels of at least one protein; and circuitry having instructions to repeatedly electrify said at least one electrode at time intervals defining delays between successive applications, during which said delays said modified protein activation level decays, and said electrifying timed to increase said protein activation levels of said at least one protein (i) beyond an amount achieved by a natural and/or paced excitation of said heart absent said application and (ii) by an amount at least as high as a decay of said protein activation level between applications of said field wherein said electrifying comprises increasing a protein activation level of protein already synthesized before said applying. - View Dependent Claims (41, 42, 43)
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Specification