Isothiocyanate functional surfactant and associated method of use

• US 9,932,306 B2
• Filed: 10/12/2015
• Issued: 04/03/2018
• Est. Priority Date: 01/03/2011
• Status: Active Grant

• Current Assignee: The William M. Yarbrough Foundation
• Original Assignee: The William M. Yarbrough Foundation
• Inventors: Silver, Michael E.
• Primary Examiner(s): NEAGU, IRINA
• Application Number:
  US14/880,418
• Publication Number:
  US 20160030380A1
• Time in Patent Office: 904 Days
• Field of Search: 514514, 514562, 514563, 514625, 514663, 514665, 558 17
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/145 having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2) isothiourea A61K31/155
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: C07C 331/20 of a saturated carbon skeleton

Abstract

A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Claims

1. A method for treating phytophotodermatitis with a lysine derivative surfactant having an isothiocyanate functional group, comprising the step(s) of:

applying a lysine derivative surfactant to an area affected by phytophotodermatitis, wherein the lysine derivative surfactant comprises an alkanoyl substituent containing at least 8 carbon atoms is bound to the α

-nitrogen of the lysine, and further wherein the ϵ

-nitrogen of the lysine forms part of an isothiocyanate functional group.

2. The method according to claim 1, further comprising the step of applying an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

3. The method according to claim 1, further comprising the step of applying an additional surfactant, wherein the additional surfactant comprises a non-ionic surfactant.

4. The method according to claim 1, further comprising the step of applying an additional surfactant, wherein the additional surfactant comprises an anionic surfactant.

5. The method according to claim 1, further comprising the step of applying an additional surfactant, wherein the additional surfactant comprises a cationic surfactant.

6. The method according to claim 1, further comprising the step of applying an additional surfactant, wherein the additional surfactant comprises a zwitterionic surfactant.

7. A method for treating phytophotodermatitis with a lysine derivative surfactant having an isothiocyanate functional group, consisting essentially of the step of:

applying a lysine derivative surfactant to an area affected by phytophotodermatitis, wherein the lysine derivative surfactant comprises an alkanoyl substituent at least 8 carbon atoms bound to the α

-nitrogen of the lysine, and further wherein the ϵ

-nitrogen of the lysine forms part of an isothiocyanate functional group.

8. A method for treating phytophotodermatitis with a lysine derivative surfactant having an isothiocyanate functional group, consisting of the step of:

applying a lysine derivative surfactant to an area affected by phytophotodermatitis, wherein the lysine derivative surfactant comprises an alkanoyl substituent at least 8 carbon atoms bound to the α

-nitrogen of the lysine, and further wherein the ϵ

-nitrogen of the lysine forms part of an isothiocyanate functional group.