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Human monoclonal antibodies specific for glypican-3 and use thereof

  • US 9,932,406 B2
  • Filed: 04/05/2016
  • Issued: 04/03/2018
  • Est. Priority Date: 04/19/2011
  • Status: Active Grant
First Claim
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1. A chimeric antigen receptor (CAR), comprising a human variable heavy (VH) single-domain monoclonal antibody that binds glypican-3 (GPC3), wherein the monoclonal antibody comprises the complementarity determining region (CDR) 1, CDR2 and CDR3 sequences of SEQ ID NO:

  • 2.

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