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Compositions and methods for modulating apolipoprotein C-III expression

  • US 9,932,581 B2
  • Filed: 08/28/2015
  • Issued: 04/03/2018
  • Est. Priority Date: 05/01/2013
  • Status: Active Grant
First Claim
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1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12 to 30 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is at least 80% complementary to an equal length portion of nucleobases 1 to 3532 or 3553 to 3958 of SEQ ID NO:

  • 3; and

    wherein the conjugate group comprises;

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